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BCL2-like 11 intron 2 deletion polymorphism is not associated with non-small cell lung cancer risk and prognosis

Authors
 Eun Na Cho  ;  Eun Young Kim  ;  Ji Ye Jung  ;  Arum Kim  ;  In Jae Oh  ;  Young Chul Kim  ;  Yoon Soo Chang 
Citation
 Lung Cancer, Vol.90(1) : 106-110, 2015 
Journal Title
 Lung Cancer 
ISSN
 0169-5002 
Issue Date
2015
Abstract
OBJECTIVES: BCL2-Like 11(BIM), which encodes a BH3-only protein, is a major pro-apoptotic molecule that facilitates cell death. We hypothesized that a BIM intron 2 deletion polymorphism increases lung cancer risk and predicts poor prognosis in non-small lung cancer (NSCLC) patients. MATERIALS AND METHODS: We prospectively recruited 450 lung cancer patients and 1:1 age, sex, and smoking status matched control subjects from February 2013 to April 2014 among patients treated at Severance, Gangnam Severance, and Chonnam Hwasoon Hospital. The presence of a 2903-bp genomic DNA deletion polymorphism of intron 2 of BIM was analyzed by PCR and validated by sequencing. Odds ratios were calculated by chi-square tests and survival analysis with Kaplan-Meier estimation. RESULTS AND CONCLUSION: Sixty-nine out of 450 (15.3%) lung cancer patients carried the BIM deletion polymorphism, while 66 out of 450 (14.7%) control subjects carried the BIM deletion polymorphism, with an odds ratio of for lung cancer of 1.054 (95% CI; 0.731-1.519). We categorized 406 NSCLC patients according to the presence of the polymorphism and found that there were no statistically significant differences in age, sex, histologic type, or stage between subjects with and without the deletion polymorphism. The BIM deletion polymorphism did not influence overall survival (OS) or progression free survival (PFS) in our sample (OS; 37.6 vs 34.4 months (P=0.759), PFS; 49.6 vs 26.0 months (P=0.434)). These findings indicate that the BIM deletion polymorphism is common in Korean NSCLC patients but does not significantly affect the intrinsic biologic function of BH3-only protein. Furthermore, the BIM deletion polymorphism did not predict clinical outcomes in patients with NSCLC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141076
DOI
10.1016/j.lungcan.2015.07.017
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김아름(Kim, A Rum)
김은영(Kim, Eun Young)
장윤수(Chang, Yoon Soo)
정지예(Jung, Ji Ye)
조은나(Cho, Eun Na)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0169500215300234
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