Cited 1 times in
Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 허단 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 구민희 | - |
dc.contributor.author | 박상욱 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2016-02-04T11:39:02Z | - |
dc.date.available | 2016-02-04T11:39:02Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140894 | - |
dc.description.abstract | The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Asialoglycoprotein Receptor/metabolism | - |
dc.subject.MESH | Drug Delivery Systems/methods* | - |
dc.subject.MESH | Galactose/chemistry* | - |
dc.subject.MESH | Genetic Vectors/chemistry | - |
dc.subject.MESH | Genetic Vectors/genetics* | - |
dc.subject.MESH | Genetic Vectors/pharmacology | - |
dc.subject.MESH | Genetic Vectors/toxicity | - |
dc.subject.MESH | Hep G2 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipid Metabolism/genetics* | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Magnetite Nanoparticles/chemistry* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | RNA Interference/drug effects* | - |
dc.title | Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Chanjoo Lee | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Sahng Wook Park | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.identifier.doi | 10.1088/0957-4484/26/33/335101 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04346 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A01487 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J02287 | - |
dc.identifier.eissn | 1361-6528 | - |
dc.identifier.pmid | 26226410 | - |
dc.identifier.url | http://stacks.iop.org/0957-4484/26/335101 | - |
dc.subject.keyword | magnetic nanovector | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | galactosyl | - |
dc.subject.keyword | asialoglycoprotein receptor, RNA interference | - |
dc.contributor.alternativeName | Heo, Dan | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.alternativeName | Park, Sahng Wook | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Lee, Chan Joo | - |
dc.contributor.affiliatedAuthor | Heo, Dan | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Ku, Min Hee | - |
dc.contributor.affiliatedAuthor | Park, Sahng Wook | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Lee, Chan Joo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 335101 | - |
dc.identifier.bibliographicCitation | NANOTECHNOLOGY, Vol.26(33) : 335101, 2015 | - |
dc.identifier.rimsid | 30376 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.