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Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging

DC FieldValueLanguage
dc.contributor.author허단-
dc.contributor.author허용민-
dc.contributor.author구민희-
dc.contributor.author박상욱-
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author이찬주-
dc.date.accessioned2016-02-04T11:39:02Z-
dc.date.available2016-02-04T11:39:02Z-
dc.date.issued2015-
dc.identifier.issn0957-4484-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140894-
dc.description.abstractThe specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNanotechnology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAsialoglycoprotein Receptor/metabolism-
dc.subject.MESHDrug Delivery Systems/methods*-
dc.subject.MESHGalactose/chemistry*-
dc.subject.MESHGenetic Vectors/chemistry-
dc.subject.MESHGenetic Vectors/genetics*-
dc.subject.MESHGenetic Vectors/pharmacology-
dc.subject.MESHGenetic Vectors/toxicity-
dc.subject.MESHHep G2 Cells-
dc.subject.MESHHumans-
dc.subject.MESHLipid Metabolism/genetics*-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMagnetite Nanoparticles/chemistry*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHRNA Interference/drug effects*-
dc.titleGalactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorDan Heo-
dc.contributor.googleauthorChanjoo Lee-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorSeungjoo Haam-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSahng Wook Park-
dc.contributor.googleauthorJaemoon Yang-
dc.identifier.doi10.1088/0957-4484/26/33/335101-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04346-
dc.contributor.localIdA04359-
dc.contributor.localIdA00191-
dc.contributor.localIdA01487-
dc.contributor.localIdA01916-
dc.contributor.localIdA02315-
dc.contributor.localIdA03238-
dc.relation.journalcodeJ02287-
dc.identifier.pmid26226410-
dc.identifier.urlhttp://stacks.iop.org/0957-4484/26/335101-
dc.subject.keywordmagnetic nanovector-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordgalactosyl-
dc.subject.keywordasialoglycoprotein receptor, RNA interference-
dc.contributor.alternativeNameHeo, Dan-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.alternativeNameKu, Min Hee-
dc.contributor.alternativeNamePark, Sahng Wook-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameLee, Chan Joo-
dc.contributor.affiliatedAuthorHeo, Dan-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.contributor.affiliatedAuthorKu, Min Hee-
dc.contributor.affiliatedAuthorPark, Sahng Wook-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorLee, Chan Joo-
dc.rights.accessRightsnot free-
dc.citation.volume26-
dc.citation.number33-
dc.citation.startPage335101-
dc.identifier.bibliographicCitationNanotechnology, Vol.26(33) : 335101, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers

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