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Comparative Study of Pulpal Responses to Pulpotomy with ProRoot MTA, RetroMTA, and TheraCal in Dogs' Teeth

 Haewon Lee  ;  Yooseok Shin  ;  Seong Oh Kim  ;  Hyo Seol Lee  ;  Hyung Jun Choi  ;  Je Seon Song 
 JOURNAL OF ENDODONTICS, Vol.41(8) : 1317-1324, 2015 
Journal Title
Issue Date
Aluminum Compounds* ; Animals ; Calcium Compounds* ; Dental Pulp/immunology* ; Dental Pulp/pathology ; Dental Pulp Capping/adverse effects ; Dental Pulp Capping/methods* ; Dogs ; Drug Combinations ; Extracellular Matrix Proteins/metabolism ; Immunohistochemistry ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Osteocalcin/metabolism ; Oxides* ; Phosphoproteins/metabolism ; Pulpotomy/adverse effects ; Pulpotomy/methods* ; Random Allocation ; Sialoglycoproteins/metabolism ; Silicates*
Calcific barrier ; inflammation ; mineral trioxide aggregate ; odontoblastic layer ; partial pulpotomy ; pulpal response
INTRODUCTION: This study was conducted to evaluate and compare pulpal responses to ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK), RetroMTA (Meta Biomed Co, Ltd, Seoul, Korea), and TheraCal (Bisco Inc, Schamburg, IL) in dog partial pulpotomy models. METHODS: Partial pulpotomies were performed on 60 beagle teeth. The exposed pulp tissues were randomly capped with either ProRoot MTA (n = 15), RetroMTA (n = 15), TheraCal (n = 15), or interim restorative material as a negative control (n = 15). After 4 weeks, the teeth were extracted and processed for histologic and immunohistochemical examinations using osteocalcin and dentin sialoprotein. Calcific barrier formation, inflammatory reaction, and the odontoblastic layer were evaluated and scored in a blind manner. The areas of newly formed calcific barriers were measured for each group. RESULTS: In most of the ProRoot MTA and RetroMTA specimens, continuous calcific barriers were formed, and the pulps contained palisading patterns in the odontoblastic layer that were free of inflammation. However, the TheraCal specimens had lower quality calcific barrier formation, extensive inflammation, and less favorable odontoblastic layer formation. Overall, areas of newly formed calcific barrier were higher in the ProRoot MTA and RetroMTA specimens than in the TheraCal specimens. Also, immunohistochemistry revealed that osteocalcin and dentin sialoprotein were more clearly visible in the ProRoot MTA and RetroMTA specimens than in the TheraCal specimens. CONCLUSIONS: RetroMTA could provide an alternative to ProRoot MTA. Both materials produced favorable pulpal responses that were similar in nature, whereas TheraCal produced less favorable pulpal responses.
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2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Oh(김성오) ORCID logo https://orcid.org/0000-0002-8620-1377
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Shin, Yoo Seok(신유석) ORCID logo https://orcid.org/0000-0003-1121-2570
Lee, Hyo Seol(이효설)
Choi, Hyung Jun(최형준) ORCID logo https://orcid.org/0000-0002-3315-6912
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