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Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

Authors
 Ilkoo Noh  ;  Hyun-Ouk Kim  ;  Jihye Choi  ;  Yuna Choi  ;  Dong Ki Lee  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Biomaterials, Vol.53 : 763-774, 2015 
Journal Title
 Biomaterials 
ISSN
 0142-9612 
Issue Date
2015
Abstract
Multi-drug delivery focuses on different signaling pathways in cancer cells that have synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers (MPDNCs) consisting of poly (l-lysine)-carboxylate PTX (PLL-PTX) and hyaluronic acid-conjugated GEM (HA-GEM) for CD44-targeted synergistic biliary cancer therapy. An in vitro study of cell viability and mRNA expression levels and an in vivo study showed that MPDNCs more effectively inhibit proliferation in CD44-overexpressing cancer cells (HuCCT1) than in cells with lower CD44 expression (SCK) by synergistically inducing apoptosis. Consequently, these results demonstrate that MPDNCs are prodrugs with synergistic cancer therapeutic efficacy and effective cellular uptake at target cells compared to free drugs, indicating their strong potential as efficient multi-drug-carrying nano-platforms for cancer treatment.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961215002768
DOI
10.1016/j.biomaterials.2015.03.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
이동기(Lee, Dong Ki) ORCID logo https://orcid.org/0000-0002-0048-9112
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140158
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