Cited 109 times in
Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동기 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2016-02-04T11:19:08Z | - |
dc.date.available | 2016-02-04T11:19:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140158 | - |
dc.description.abstract | Multi-drug delivery focuses on different signaling pathways in cancer cells that have synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers (MPDNCs) consisting of poly (l-lysine)-carboxylate PTX (PLL-PTX) and hyaluronic acid-conjugated GEM (HA-GEM) for CD44-targeted synergistic biliary cancer therapy. An in vitro study of cell viability and mRNA expression levels and an in vivo study showed that MPDNCs more effectively inhibit proliferation in CD44-overexpressing cancer cells (HuCCT1) than in cells with lower CD44 expression (SCK) by synergistically inducing apoptosis. Consequently, these results demonstrate that MPDNCs are prodrugs with synergistic cancer therapeutic efficacy and effective cellular uptake at target cells compared to free drugs, indicating their strong potential as efficient multi-drug-carrying nano-platforms for cancer treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 763~774 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/administration & dosage* | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/pharmacology | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Biliary Tract Neoplasms/drug therapy* | - |
dc.subject.MESH | Biliary Tract Neoplasms/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Deoxycytidine/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/analogs & derivatives | - |
dc.subject.MESH | Drug Carriers* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronan Receptors/drug effects* | - |
dc.subject.MESH | Nanoparticles* | - |
dc.subject.MESH | Paclitaxel/administration & dosage | - |
dc.title | Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ilkoo Noh | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Yuna Choi | - |
dc.contributor.googleauthor | Dong Ki Lee | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1016/j.biomaterials.2015.03.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02723 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 25890771 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961215002768 | - |
dc.subject.keyword | Biliary cancer | - |
dc.subject.keyword | CD44 targeting | - |
dc.subject.keyword | Combined cancer therapy | - |
dc.subject.keyword | Gemcitabine | - |
dc.subject.keyword | Paclitaxel | - |
dc.subject.keyword | Polymeric prodrug | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Lee, Dong Ki | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 53 | - |
dc.citation.startPage | 763 | - |
dc.citation.endPage | 774 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.53 : 763-774, 2015 | - |
dc.identifier.rimsid | 53935 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.