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Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport

Authors
 Eun Bi Choi  ;  Jihye Choi  ;  Seo Ryung Bae  ;  Hyun-Ouk Kim  ;  Eunji Jang  ;  Byunghoon Kang  ;  Myeong-Hoon Kim  ;  Byeongyoon Kim  ;  Jin-Suck Suh  ;  Kwangyeol Lee  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Nano Research, Vol.8(4) : 1169-1179, 2015 
Journal Title
 Nano Research 
ISSN
 1998-0124 
Issue Date
2015
Abstract
Vesicular pH modulates the function of many organelles and plays a pivotal role in cell metabolism processes such as proliferation and apoptosis. Here, we introduce a simple colourimetric redox-polyaniline nanoindicator, which can detect and quantify a broader biogenic pH range with superior sensitivity compared to pre-established trafficking agents employing one-dimensional turn-on of the FRET signal. We fabricated polyaniline-based nanoprobes, which exhibited convertible transition states according to the proton levels, as an in situ indicator of vesicular transport pH. Silica-coated Fe3O4–MnO heterometal nanoparticles were synthesised and utilised as a metal oxidant to polymerise the aniline monomer. Finally, silica-coated polyaniline nanoparticles with adsorbed fluorophores Cy3 and Cy7 (FPSNICy3 and FPSNICy7) were fabricated as proton-sensitive nanoindicators. Owing to the selective quenching induced by the local pH variations of vesicular transport, FPSNICy3 and FPSNICy7 demonstrated excellent intracellular trafficking and provided sensitive optical indication of minute proton levels.
DOI
10.1007/s12274-014-0597-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140157
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