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Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies

Authors
 Jung Min Bae  ;  Yoon Young Choi  ;  Dae Suk Kim  ;  Ji Hye Lee  ;  Hong Sun Jang  ;  Joo Hee Lee  ;  Heesu Kim  ;  Byung Ho Oh  ;  Mi Ryung Roh  ;  Kyoung Ae Nam  ;  Kee Yang Chung 
Citation
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.72(1) : 59-70, 2015 
Journal Title
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 
ISSN
 0190-9622 
Issue Date
2015
MeSH
Humans ; Melanoma/mortality* ; Melanoma/secondary* ; Neoplasms, Unknown Primary/mortality* ; Observational Studies as Topic ; Prognosis ; Risk Factors ; Skin Neoplasms/mortality* ; Skin Neoplasms/pathology* ; Survival Rate
Keywords
malignant melanoma ; melanoma ; melanoma, unknown primary ; meta-analysis ; prognosis ; systematic review
Abstract
BACKGROUND: Melanoma of unknown primary (MUP) is a condition of metastatic melanoma without a primary lesion. OBJECTIVE: We sought to identify the prognosis of MUP compared with melanoma of known primary (MKP). METHODS: We searched for observational studies containing at least 10 patients with MUP from MEDLINE and EMBASE from inception to December 22, 2012. The outcomes of interest were overall and disease-free survival; meta-analyses of hazard ratio stratified by stage using a random effects model were performed. In addition, second systematic review identified risk factors influencing the survival of patients with MUP. RESULTS: Eighteen studies including 2084 patients with MUP and 5894 with MKP were included. MUP had a better overall survival compared with MKP in stage III (15 studies; hazard ratio 0.83, 95% confidence interval 0.73-0.96, P = .010) and stage IV (6 studies; hazard ratio 0.85, 95% confidence interval 0.75-0.96, P = .008). Secondly, 22 studies including 3312 patients with MUP were reviewed, and increased stage and old age were the risk factors in patients with MUP. LIMITATIONS: Diverse observational studies were reviewed, and selection and reporting biases are possible. CONCLUSIONS: The current meta-analyses suggest better survival outcomes in patients with MUP than those in patients with MKP with the same corresponding tumor stage.
Full Text
http://www.sciencedirect.com/science/article/pii/S0190962214019653
DOI
10.1016/j.jaad.2014.09.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Suk(김대석)
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Bae, Jung Min(배정민)
Oh, Byung Ho(오병호) ORCID logo https://orcid.org/0000-0001-9575-5665
Lee, Ji Hye(이지혜)
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
Choi, Yoon Young(최윤영) ORCID logo https://orcid.org/0000-0002-2179-7851
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140144
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