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Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies
DC Field | Value | Language |
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dc.contributor.author | 김대석 | - |
dc.contributor.author | 노미령 | - |
dc.contributor.author | 배정민 | - |
dc.contributor.author | 오병호 | - |
dc.contributor.author | 이지혜 | - |
dc.contributor.author | 정기양 | - |
dc.contributor.author | 최윤영 | - |
dc.date.accessioned | 2016-02-04T11:18:45Z | - |
dc.date.available | 2016-02-04T11:18:45Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0190-9622 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140144 | - |
dc.description.abstract | BACKGROUND: Melanoma of unknown primary (MUP) is a condition of metastatic melanoma without a primary lesion. OBJECTIVE: We sought to identify the prognosis of MUP compared with melanoma of known primary (MKP). METHODS: We searched for observational studies containing at least 10 patients with MUP from MEDLINE and EMBASE from inception to December 22, 2012. The outcomes of interest were overall and disease-free survival; meta-analyses of hazard ratio stratified by stage using a random effects model were performed. In addition, second systematic review identified risk factors influencing the survival of patients with MUP. RESULTS: Eighteen studies including 2084 patients with MUP and 5894 with MKP were included. MUP had a better overall survival compared with MKP in stage III (15 studies; hazard ratio 0.83, 95% confidence interval 0.73-0.96, P = .010) and stage IV (6 studies; hazard ratio 0.85, 95% confidence interval 0.75-0.96, P = .008). Secondly, 22 studies including 3312 patients with MUP were reviewed, and increased stage and old age were the risk factors in patients with MUP. LIMITATIONS: Diverse observational studies were reviewed, and selection and reporting biases are possible. CONCLUSIONS: The current meta-analyses suggest better survival outcomes in patients with MUP than those in patients with MKP with the same corresponding tumor stage. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Melanoma/mortality* | - |
dc.subject.MESH | Melanoma/secondary* | - |
dc.subject.MESH | Neoplasms, Unknown Primary/mortality* | - |
dc.subject.MESH | Observational Studies as Topic | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Skin Neoplasms/mortality* | - |
dc.subject.MESH | Skin Neoplasms/pathology* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Jung Min Bae | - |
dc.contributor.googleauthor | Yoon Young Choi | - |
dc.contributor.googleauthor | Dae Suk Kim | - |
dc.contributor.googleauthor | Ji Hye Lee | - |
dc.contributor.googleauthor | Hong Sun Jang | - |
dc.contributor.googleauthor | Joo Hee Lee | - |
dc.contributor.googleauthor | Heesu Kim | - |
dc.contributor.googleauthor | Byung Ho Oh | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Kyoung Ae Nam | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.identifier.doi | 10.1016/j.jaad.2014.09.029 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00366 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A01804 | - |
dc.contributor.localId | A02367 | - |
dc.contributor.localId | A03220 | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J01766 | - |
dc.identifier.eissn | 1097-6787 | - |
dc.identifier.pmid | 25440435 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0190962214019653 | - |
dc.subject.keyword | malignant melanoma | - |
dc.subject.keyword | melanoma | - |
dc.subject.keyword | melanoma, unknown primary | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | systematic review | - |
dc.contributor.alternativeName | Kim, Dae Suk | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.alternativeName | Bae, Jung Min | - |
dc.contributor.alternativeName | Oh, Byung Ho | - |
dc.contributor.alternativeName | Lee, Ji Hye | - |
dc.contributor.alternativeName | Chung, Kee Yang | - |
dc.contributor.affiliatedAuthor | Kim, Dae Suk | - |
dc.contributor.affiliatedAuthor | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | Bae, Jung Min | - |
dc.contributor.affiliatedAuthor | Oh, Byung Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hye | - |
dc.contributor.affiliatedAuthor | Chung, Kee Yang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.72(1) : 59-70, 2015 | - |
dc.identifier.rimsid | 53925 | - |
dc.type.rims | ART | - |
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