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Metastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies

DC FieldValueLanguage
dc.contributor.author김대석-
dc.contributor.author노미령-
dc.contributor.author배정민-
dc.contributor.author오병호-
dc.contributor.author이지혜-
dc.contributor.author정기양-
dc.contributor.author최윤영-
dc.date.accessioned2016-02-04T11:18:45Z-
dc.date.available2016-02-04T11:18:45Z-
dc.date.issued2015-
dc.identifier.issn0190-9622-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140144-
dc.description.abstractBACKGROUND: Melanoma of unknown primary (MUP) is a condition of metastatic melanoma without a primary lesion. OBJECTIVE: We sought to identify the prognosis of MUP compared with melanoma of known primary (MKP). METHODS: We searched for observational studies containing at least 10 patients with MUP from MEDLINE and EMBASE from inception to December 22, 2012. The outcomes of interest were overall and disease-free survival; meta-analyses of hazard ratio stratified by stage using a random effects model were performed. In addition, second systematic review identified risk factors influencing the survival of patients with MUP. RESULTS: Eighteen studies including 2084 patients with MUP and 5894 with MKP were included. MUP had a better overall survival compared with MKP in stage III (15 studies; hazard ratio 0.83, 95% confidence interval 0.73-0.96, P = .010) and stage IV (6 studies; hazard ratio 0.85, 95% confidence interval 0.75-0.96, P = .008). Secondly, 22 studies including 3312 patients with MUP were reviewed, and increased stage and old age were the risk factors in patients with MUP. LIMITATIONS: Diverse observational studies were reviewed, and selection and reporting biases are possible. CONCLUSIONS: The current meta-analyses suggest better survival outcomes in patients with MUP than those in patients with MKP with the same corresponding tumor stage.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHHumans-
dc.subject.MESHMelanoma/mortality*-
dc.subject.MESHMelanoma/secondary*-
dc.subject.MESHNeoplasms, Unknown Primary/mortality*-
dc.subject.MESHObservational Studies as Topic-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk Factors-
dc.subject.MESHSkin Neoplasms/mortality*-
dc.subject.MESHSkin Neoplasms/pathology*-
dc.subject.MESHSurvival Rate-
dc.titleMetastatic melanomas of unknown primary show better prognosis than those of known primary: a systematic review and meta-analysis of observational studies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorJung Min Bae-
dc.contributor.googleauthorYoon Young Choi-
dc.contributor.googleauthorDae Suk Kim-
dc.contributor.googleauthorJi Hye Lee-
dc.contributor.googleauthorHong Sun Jang-
dc.contributor.googleauthorJoo Hee Lee-
dc.contributor.googleauthorHeesu Kim-
dc.contributor.googleauthorByung Ho Oh-
dc.contributor.googleauthorMi Ryung Roh-
dc.contributor.googleauthorKyoung Ae Nam-
dc.contributor.googleauthorKee Yang Chung-
dc.identifier.doi10.1016/j.jaad.2014.09.029-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00366-
dc.contributor.localIdA01278-
dc.contributor.localIdA01804-
dc.contributor.localIdA02367-
dc.contributor.localIdA03220-
dc.contributor.localIdA03582-
dc.relation.journalcodeJ01766-
dc.identifier.eissn1097-6787-
dc.identifier.pmid25440435-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0190962214019653-
dc.subject.keywordmalignant melanoma-
dc.subject.keywordmelanoma-
dc.subject.keywordmelanoma, unknown primary-
dc.subject.keywordmeta-analysis-
dc.subject.keywordprognosis-
dc.subject.keywordsystematic review-
dc.contributor.alternativeNameKim, Dae Suk-
dc.contributor.alternativeNameRoh, Mi Ryung-
dc.contributor.alternativeNameBae, Jung Min-
dc.contributor.alternativeNameOh, Byung Ho-
dc.contributor.alternativeNameLee, Ji Hye-
dc.contributor.alternativeNameChung, Kee Yang-
dc.contributor.affiliatedAuthorKim, Dae Suk-
dc.contributor.affiliatedAuthorRoh, Mi Ryung-
dc.contributor.affiliatedAuthorBae, Jung Min-
dc.contributor.affiliatedAuthorOh, Byung Ho-
dc.contributor.affiliatedAuthorLee, Ji Hye-
dc.contributor.affiliatedAuthorChung, Kee Yang-
dc.rights.accessRightsnot free-
dc.citation.volume72-
dc.citation.number1-
dc.citation.startPage59-
dc.citation.endPage70-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.72(1) : 59-70, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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