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Clinical Implication of Highly Sensitive Detection of the BRAFV600E Mutation in Fine-Needle Aspirations According to the Thyroid Bethesda System in Patients With Conventional Papillary Thyroid Carcinoma

Authors
 Jae Young Seo  ;  Jong Rak Choi  ;  Hee Jung Moon  ;  Eun-Kyung Kim  ;  Kyung Hwa Han  ;  Hyunki Kim  ;  Jin Young Kwak 
Citation
 ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, Vol.124(5) : 392-399, 2015 
Journal Title
 ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 
ISSN
 0003-4894 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aged ; Biopsy, Fine-Needle ; Carcinoma/genetics* ; Carcinoma/metabolism ; Carcinoma/pathology ; Carcinoma, Papillary ; DNA Mutational Analysis ; DNA, Neoplasm/genetics* ; Female ; Humans ; Male ; Middle Aged ; Mutation* ; Proto-Oncogene Proteins B-raf/genetics* ; Proto-Oncogene Proteins B-raf/metabolism ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Retrospective Studies ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology ; Young Adult
Keywords
biopsy ; cytology ; fine-needle ; mutation ; papillary ; proto-oncogene proteins BRAF ; thyroid cancer
Abstract
BACKGROUND: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. MATERIALS AND METHODS: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. RESULTS: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. CONCLUSIONS: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.
Full Text
http://aor.sagepub.com/content/124/5/392.long
DOI
10.1177/0003489414560433
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139869
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