Cited 13 times in
Clinical Implication of Highly Sensitive Detection of the BRAFV600E Mutation in Fine-Needle Aspirations According to the Thyroid Bethesda System in Patients With Conventional Papillary Thyroid Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 최종락 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2016-02-04T11:11:29Z | - |
dc.date.available | 2016-02-04T11:11:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0003-4894 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139869 | - |
dc.description.abstract | BACKGROUND: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. MATERIALS AND METHODS: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. RESULTS: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. CONCLUSIONS: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 392~399 | - |
dc.relation.isPartOf | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Carcinoma/genetics* | - |
dc.subject.MESH | Carcinoma/metabolism | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma, Papillary | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | DNA, Neoplasm/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/metabolism | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Thyroid Neoplasms/genetics* | - |
dc.subject.MESH | Thyroid Neoplasms/metabolism | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinical Implication of Highly Sensitive Detection of the BRAFV600E Mutation in Fine-Needle Aspirations According to the Thyroid Bethesda System in Patients With Conventional Papillary Thyroid Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jae Young Seo | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Kyung Hwa Han | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.identifier.doi | 10.1177/0003489414560433 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A04182 | - |
dc.contributor.localId | A04267 | - |
dc.relation.journalcode | J00173 | - |
dc.identifier.eissn | 1943-572X | - |
dc.identifier.pmid | 25404749 | - |
dc.identifier.url | http://aor.sagepub.com/content/124/5/392.long | - |
dc.subject.keyword | biopsy | - |
dc.subject.keyword | cytology | - |
dc.subject.keyword | fine-needle | - |
dc.subject.keyword | mutation | - |
dc.subject.keyword | papillary | - |
dc.subject.keyword | proto-oncogene proteins BRAF | - |
dc.subject.keyword | thyroid cancer | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Han, Kyung Hwa | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 124 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 392 | - |
dc.citation.endPage | 399 | - |
dc.identifier.bibliographicCitation | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, Vol.124(5) : 392-399, 2015 | - |
dc.identifier.rimsid | 46610 | - |
dc.type.rims | ART | - |
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