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Left atrial volume index is an independent predictor of hypertensive response to exercise in patients with hypertension

 Sang-Eun Lee  ;  Jong-Chan Youn  ;  Hye Sun Lee  ;  Sungha Park  ;  Sang-Hak Lee  ;  In-Jeong Cho  ;  Chi Young Shim  ;  Geu-Ru Hong  ;  Donghoon Choi  ;  Seok-Min Kang 
 HYPERTENSION RESEARCH, Vol.38(2) : 137-142, 2015 
Journal Title
Issue Date
Aged ; Blood Pressure/physiology* ; Echocardiography ; Exercise/physiology* ; Exercise Test ; Female ; Heart Atria/diagnostic imaging* ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology* ; Hypertrophy, Left Ventricular/diagnostic imaging* ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged
Cardiopulmonary exercise test ; hypertensive response to exercise ; left atrial volume inde
A hypertensive response to exercise (HRE) is known to be associated with higher risk of heart failure and future cardiovascular events in patients with hypertension. Left atrial volume index (LAVI) is associated with the diastolic dysfunction, indicating exercise intolerance. Therefore, we investigated whether LAVI is relevant to HRE during cardiopulmonary exercise test (CPET). We studied 118 consecutive hypertensive patients (61 men, 57±11 years) and 45 normotensive control subjects (16 men, 54±8 years). Clinical characteristics, CPET, echocardiographic and laboratory findings were assessed at the time of enrollment. HRE was defined as maximum systolic blood pressure (SBP)⩾210 mm Hg in men and ⩾190 mm Hg in women. HRE was more prevalent in hypertensive patients compared with normotensive control subjects (50.8% vs. 20.0%, P<0.001). Age and baseline SBP were shown to be associated with HRE in normotensive control subjects, as were baseline SBP and LAVI in hypertensive group. In multivariate analysis, LAVI was found to be an independent predictor of HRE in hypertensive patients (P=0.020) but not in normotensive control subjects (P=0.936) when controlled for age, sex, body mass index and peak oxygen consumption. Higher LAVI, reflecting the duration and severity of increased left atrial pressure is independently associated with HRE in hypertensive patients, but not in normotensive control subjects.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Youn, Jong Chan(윤종찬)
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0001-6645-4038
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, In Jeong(조인정)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
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