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Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study

 Ah Young Park  ;  Eun Ju Son  ;  Kyunghwa Han  ;  Ji Hyun Youk  ;  Jeong-Ah Kim  ;  Cheong Soo Park 
 EUROPEAN JOURNAL OF RADIOLOGY, Vol.84(3) : 407-412, 2015 
Journal Title
Issue Date
Adult ; Aged ; Biopsy, Fine-Needle ; Elasticity Imaging Techniques* ; Female ; Humans ; Male ; Microsurgery ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging* ; Thyroid Nodule/pathology
Malignancy ; Shear wave elastography ; Thyroid nodule
OBJECTIVES: The purpose of this study is to validate the usefulness of shear wave elastography (SWE) in predicting thyroid malignancy with a large-scale quantitative SWE data. METHODS: This restrospective study included 476 thyroid nodules in 453 patients who underwent gray-scale US and SWE before US-guided fine-needle aspiration biopsy (US-FNA) or surgical excision were included. Gray-scale findings and SWE elasticity indices (EIs) were retrospectively reviewed and compared between benign and malignant thyroid nodules. The optimal cut-off values of EIs for predicting malignancy were determined. The diagnostic performances of gray-scale US and SWE for predicting malignancy were analyzed. The diagnostic performance was compared between the gray-scale US findings only and the combined use of gray-scale US findings with SWEs. RESULTS: All EIs of malignant thyroid nodules were significantly higher than those of benign nodules (p≤.001). The optimal cut-off value of each EI for predicting malignancy was 85.2kPa of Emean, 94.0kPa of Emax, 54.0kPa of Emin. Emean (OR 3.071, p=.005) and Emax (OR 3.015, p=.003) were the independent predictors of thyroid malignancy. Combined use of gray-scale US findings and each EI showed elevated sensitivity (95.0-95.5% vs 92.9%, p≤.005) and AUC (0.820-0.834 vs 0.769, p≤.005) for predicting malignancy, compared with the use of only gray-scale US findings. CONCLUSIONS: Quantitative parameters of SWE were the independent predictors of thyroid malignancy and SWE evaluation combined with gray-scale US was adjunctive to the diagnostic performance of gray-scale US for predicting thyroid malignancy.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Park, Ah Young(박아영)
Park, Cheong Soo(박정수)
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
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