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A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent

Authors
 Joseph Park  ;  Byunghoon Kang  ;  Bongjune Kim  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 NANO CONVERGENCE, (1) : 3, 2015 
Journal Title
 NANO CONVERGENCE 
Issue Date
2015
Keywords
Relaxivity ; Coating thickness ; Manganese-doped nanocrystal ; Sensitivity ; MRI
Abstract
We describe a systematic study of coating thickness and their effect on different core sizes for the optimized preparation of highly sensitive manganese-doped magnetic nanocrystals (MnMNCs) to be served as magnetic resonance (MR) contrast agent. From these efforts, MnMNCs with 12 nm core and DA-PEG2k coating demonstrated that T2 relaxivity (r2) was increased by 7.29-fold (r2 value: 452 mM−1 s−1) compare to conventional iron oxide (CLIO) and remarkable colloidal stability in various physiological conditions. Further in vitro cellular MR imaging results showed that MnMNC-PEGs were biocompatible and well suited for medical applications. This study will provide a useful synthetic strategy for the development of highly effective MR contrast agents.
Files in This Item:
T201500323.pdf Download
DOI
10.1186/s40580-014-0032-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139398
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