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A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2016-02-04T10:58:44Z | - |
dc.date.available | 2016-02-04T10:58:44Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139398 | - |
dc.description.abstract | We describe a systematic study of coating thickness and their effect on different core sizes for the optimized preparation of highly sensitive manganese-doped magnetic nanocrystals (MnMNCs) to be served as magnetic resonance (MR) contrast agent. From these efforts, MnMNCs with 12 nm core and DA-PEG2k coating demonstrated that T2 relaxivity (r2) was increased by 7.29-fold (r2 value: 452 mM−1 s−1) compare to conventional iron oxide (CLIO) and remarkable colloidal stability in various physiological conditions. Further in vitro cellular MR imaging results showed that MnMNC-PEGs were biocompatible and well suited for medical applications. This study will provide a useful synthetic strategy for the development of highly effective MR contrast agents. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NANO CONVERGENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A systematic study of core size and coating thickness on manganese-doped nanocrystals for high T2 relaxivity as magnetic resonance contrast agent | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Joseph Park | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Bongjune Kim | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1186/s40580-014-0032-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02282 | - |
dc.identifier.eissn | 2196-5404 | - |
dc.subject.keyword | Relaxivity | - |
dc.subject.keyword | Coating thickness | - |
dc.subject.keyword | Manganese-doped nanocrystal | - |
dc.subject.keyword | Sensitivity | - |
dc.subject.keyword | MRI | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 2 | - |
dc.citation.startPage | 3 | - |
dc.identifier.bibliographicCitation | NANO CONVERGENCE, Vol.2 : 3, 2015 | - |
dc.identifier.rimsid | 55370 | - |
dc.type.rims | ART | - |
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