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A multistep photothermic-driven drug release system using wire-framed Au nanobundles

Authors
 Doyeon Bang  ;  Taeksu Lee  ;  Jihye Choi  ;  Yeonji Park  ;  Eunkyoung Kim  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Advanced Healthcare Materials, Vol.4(2) : 255-263, 2015 
Journal Title
 Advanced Healthcare Materials 
ISSN
 2192-2640 
Issue Date
2015
Abstract
Here, wire-framed Au nanobundles (WNBs), which consist of randomly oriented and mutually connected Au wires to form a bundle shape, are synthesized. In contrast to conventional nanoparticles (spheres, rods, cubes, and stars), which exhibit nanostructure only on the surface, cross-sectional view image shows that WNBs have nanostructures in a whole volume. By using this specific property of WNBs, an externally controllable multistep photothermic-driven drug release (PDR) system is demonstrated for in vivo cancer treatment. In contrast to conventional nanoparticles that encapsulate a drug on their surface, WNBs preserve the drug payload in the overall inner volume, providing a drug loading capacity sufficient for cancer therapy. An improved in vivo therapeutic efficacy of PDR therapy is also demonstrated by delivering sufficient amount of drugs to the target tumor region.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400197/abstract
DOI
10.1002/adhm.201400197
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139397
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