Absorption, Physicochemical ; Animals ; Cell Line, Tumor ; Drug Delivery Systems/methods* ; Gold/chemistry* ; Humans ; Light* ; Metal Nanoparticles/chemistry* ; Metal Nanoparticles/ultrastructure ; Mice, Inbred BALB C ; Mice, Nude ; Microscopy, Fluorescence ; Spectroscopy, Near-Infrared ; Temperature*
Keywords
cancer therapy ; controlled release ; drug delivery ; nanoparticles ; nanostructures
Abstract
Here, wire-framed Au nanobundles (WNBs), which consist of randomly oriented and mutually connected Au wires to form a bundle shape, are synthesized. In contrast to conventional nanoparticles (spheres, rods, cubes, and stars), which exhibit nanostructure only on the surface, cross-sectional view image shows that WNBs have nanostructures in a whole volume. By using this specific property of WNBs, an externally controllable multistep photothermic-driven drug release (PDR) system is demonstrated for in vivo cancer treatment. In contrast to conventional nanoparticles that encapsulate a drug on their surface, WNBs preserve the drug payload in the overall inner volume, providing a drug loading capacity sufficient for cancer therapy. An improved in vivo therapeutic efficacy of PDR therapy is also demonstrated by delivering sufficient amount of drugs to the target tumor region.