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Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)

 Sang Joon Son  ;  Jinna Kim  ;  Eun Lee  ;  Jin Young Park  ;  Kee Namkoong  ;  Chang Hyung Hong  ;  Jeonghun Ku  ;  Eosu Kim  ;  Byoung Hoon Oh 
 Archives of Gerontology and Geriatics, Vol.60(1) : 210-216, 2015 
Journal Title
 Archives of Gerontology and Geriatics 
Issue Date
BACKGROUND/OBJECTIVES: Although hypertension is known to be a risk factor for AD, the effects of hypertension on brain function in AD patients are not well understood. We investigated alterations in resting-state functional connectivity according to the presence of hypertension in AD patients by using a method of correlation analysis based on a seed region in the posterior cingulate cortex (PCC). We also determined whether differences in resting-state connectivity were associated with gray matter atrophy. METHODS: Thirty-seven AD patients (18 patients with hypertension and 19 patients without hypertension) underwent the resting-state functional magnetic resonance imaging. We obtained the PCC maps by a temporal correlation method, to identify alterations in the functional connectivity of the PCC in hypertensive group relative to non-hypertensive group. Voxel-based morphometry analysis was also applied to adjust the confounding effect of gray matter atrophy. RESULTS: We detected a decreased connectivity to the PCC in the regions of subgenual anterior cingulated cortex (ACC) in hypertensive group relative to non-hypertensive group. However, we observed a pattern of increased connectivity between the PCC and the left inferior parietal cortex in hypertensive group. After correction for gray matter atrophy, all detected regions still remained significant. CONCLUSIONS: Altered connectivity in AD patients with hypertension suggests the possibility that hypertension impairs resting-state functional connectivity of the AD brain, inducing a compensational process outside the impaired networks or disequilibrium in brain connectivity. This finding may account for an additional contribution of hypertension to the pathophysiology of AD.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
김진아(Kim, Jinna) ORCID logo https://orcid.org/0000-0002-9978-4356
남궁기(Namkoong, Kee) ORCID logo https://orcid.org/0000-0003-1400-8057
박진영(Park, Jin Young) ORCID logo https://orcid.org/0000-0002-5351-9549
오병훈(Oh, Byong Hoon)
이은(Lee, Eun) ORCID logo https://orcid.org/0000-0002-7462-0144
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