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Doxycycline enhances survival and self-renewal of human pluripotent stem cells

Authors
 Mi Yoon Chang  ;  Yong Hee Rhee  ;  Sang Hoon Yi  ;  Su Jae Lee  ;  Rae Kwon Kim  ;  Hyongbum Kim  ;  Chang Hwan Park  ;  Sang Hun Lee 
Citation
 STEM CELL REPORTS, Vol.3(2) : 353-364, 2014 
Journal Title
STEM CELL REPORTS
Issue Date
2014
Keywords
Anti-Bacterial Agents/pharmacology* ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects* ; Cell Survival/drug effects ; Cells, Cultured ; Doxycycline/pharmacology* ; Embryonic Stem Cells/cytology ; Humans ; Karyotyping ; Neural Stem Cells/cytology ; Neurons/cytology ; Phosphatidylinositol 3-Kinases/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/drug effects* ; Pluripotent Stem Cells/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects
Abstract
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
Files in This Item:
T201406208.pdf Download
DOI
10.1016/j.stemcr.2014.06.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyongbum(김형범) ORCID logo https://orcid.org/0000-0002-4693-738X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139087
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