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Doxycycline enhances survival and self-renewal of human pluripotent stem cells

DC Field Value Language
dc.contributor.author김형범-
dc.date.accessioned2015-12-28T11:16:32Z-
dc.date.available2015-12-28T11:16:32Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139087-
dc.description.abstractWe here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.-
dc.description.statementOfResponsibilityopen-
dc.format.extent353~364-
dc.relation.isPartOfSTEM CELL REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDoxycycline enhances survival and self-renewal of human pluripotent stem cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorMi Yoon Chang-
dc.contributor.googleauthorYong Hee Rhee-
dc.contributor.googleauthorSang Hoon Yi-
dc.contributor.googleauthorSu Jae Lee-
dc.contributor.googleauthorRae Kwon Kim-
dc.contributor.googleauthorHyongbum Kim-
dc.contributor.googleauthorChang Hwan Park-
dc.contributor.googleauthorSang Hun Lee-
dc.identifier.doi10.1016/j.stemcr.2014.06.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01148-
dc.relation.journalcodeJ02679-
dc.identifier.eissn2213-6711-
dc.identifier.pmid25254347-
dc.subject.keywordAnti-Bacterial Agents/pharmacology*-
dc.subject.keywordCell Differentiation/drug effects-
dc.subject.keywordCell Proliferation/drug effects*-
dc.subject.keywordCell Survival/drug effects-
dc.subject.keywordCells, Cultured-
dc.subject.keywordDoxycycline/pharmacology*-
dc.subject.keywordEmbryonic Stem Cells/cytology-
dc.subject.keywordHumans-
dc.subject.keywordKaryotyping-
dc.subject.keywordNeural Stem Cells/cytology-
dc.subject.keywordNeurons/cytology-
dc.subject.keywordPhosphatidylinositol 3-Kinases/metabolism-
dc.subject.keywordPluripotent Stem Cells/cytology-
dc.subject.keywordPluripotent Stem Cells/drug effects*-
dc.subject.keywordPluripotent Stem Cells/metabolism-
dc.subject.keywordProto-Oncogene Proteins c-akt/metabolism-
dc.subject.keywordSignal Transduction/drug effects-
dc.contributor.alternativeNameKim, Hyongbum-
dc.contributor.affiliatedAuthorKim, Hyongbum-
dc.citation.volume3-
dc.citation.number2-
dc.citation.startPage353-
dc.citation.endPage364-
dc.identifier.bibliographicCitationSTEM CELL REPORTS, Vol.3(2) : 353-364, 2014-
dc.identifier.rimsid52478-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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