Cited 45 times in
Doxycycline enhances survival and self-renewal of human pluripotent stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형범 | - |
dc.date.accessioned | 2015-12-28T11:16:32Z | - |
dc.date.available | 2015-12-28T11:16:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139087 | - |
dc.description.abstract | We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 353~364 | - |
dc.relation.isPartOf | STEM CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Doxycycline enhances survival and self-renewal of human pluripotent stem cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Mi Yoon Chang | - |
dc.contributor.googleauthor | Yong Hee Rhee | - |
dc.contributor.googleauthor | Sang Hoon Yi | - |
dc.contributor.googleauthor | Su Jae Lee | - |
dc.contributor.googleauthor | Rae Kwon Kim | - |
dc.contributor.googleauthor | Hyongbum Kim | - |
dc.contributor.googleauthor | Chang Hwan Park | - |
dc.contributor.googleauthor | Sang Hun Lee | - |
dc.identifier.doi | 10.1016/j.stemcr.2014.06.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01148 | - |
dc.relation.journalcode | J02679 | - |
dc.identifier.eissn | 2213-6711 | - |
dc.identifier.pmid | 25254347 | - |
dc.subject.keyword | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.keyword | Cell Differentiation/drug effects | - |
dc.subject.keyword | Cell Proliferation/drug effects* | - |
dc.subject.keyword | Cell Survival/drug effects | - |
dc.subject.keyword | Cells, Cultured | - |
dc.subject.keyword | Doxycycline/pharmacology* | - |
dc.subject.keyword | Embryonic Stem Cells/cytology | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Karyotyping | - |
dc.subject.keyword | Neural Stem Cells/cytology | - |
dc.subject.keyword | Neurons/cytology | - |
dc.subject.keyword | Phosphatidylinositol 3-Kinases/metabolism | - |
dc.subject.keyword | Pluripotent Stem Cells/cytology | - |
dc.subject.keyword | Pluripotent Stem Cells/drug effects* | - |
dc.subject.keyword | Pluripotent Stem Cells/metabolism | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.keyword | Signal Transduction/drug effects | - |
dc.contributor.alternativeName | Kim, Hyongbum | - |
dc.contributor.affiliatedAuthor | Kim, Hyongbum | - |
dc.citation.volume | 3 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 353 | - |
dc.citation.endPage | 364 | - |
dc.identifier.bibliographicCitation | STEM CELL REPORTS, Vol.3(2) : 353-364, 2014 | - |
dc.identifier.rimsid | 52478 | - |
dc.type.rims | ART | - |
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