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Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model.

Authors
 Ji Won Park  ;  Sook Hee Ku  ;  Hyung Ho Moon  ;  Minhyung Lee  ;  Donghoon Choi  ;  Jaemoon Yang  ;  Yong Min Huh  ;  Ji Hoon Jeong  ;  Tae Gwan Park  ;  Hyejung Mok  ;  Sun Hwa Kim 
Citation
 MACROMOLECULAR BIOSCIENCE, Vol.14(3) : 380-389, 2014 
Journal Title
 MACROMOLECULAR BIOSCIENCE 
ISSN
 1616-5187 
Issue Date
2014
MeSH
Animals ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Brain Ischemia/therapy* ; Cell Engineering ; Cell Tracking/methods* ; Cell- and Tissue-Based Therapy/methods* ; Disease Models, Animal ; Ferric Compounds/chemistry ; Magnetic Resonance Imaging ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/metabolism* ; Nanoparticles/chemistry* ; Plasmids/chemistry ; Polyethylene Glycols/chemistry ; Rats ; Rats, Sprague-Dawley ; Transfection ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Keywords
cell engineering ; cerebral ischemia model ; cross-linked iron oxide nanoparticles ; magnetic resonance imaging ; mesenchymal stem cells
Abstract
Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201300340/abstract
DOI
10.1002/mabi.201300340
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138985
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