Cited 12 times in
Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model.
DC Field | Value | Language |
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dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-12-28T11:13:53Z | - |
dc.date.available | 2015-12-28T11:13:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138985 | - |
dc.description.abstract | Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 380~389 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain Ischemia/metabolism | - |
dc.subject.MESH | Brain Ischemia/pathology | - |
dc.subject.MESH | Brain Ischemia/therapy* | - |
dc.subject.MESH | Cell Engineering | - |
dc.subject.MESH | Cell Tracking/methods* | - |
dc.subject.MESH | Cell- and Tissue-Based Therapy/methods* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Ferric Compounds/chemistry | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology | - |
dc.subject.MESH | Mesenchymal Stromal Cells/metabolism* | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Plasmids/chemistry | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/metabolism | - |
dc.title | Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Ji Won Park | - |
dc.contributor.googleauthor | Sook Hee Ku | - |
dc.contributor.googleauthor | Hyung Ho Moon | - |
dc.contributor.googleauthor | Minhyung Lee | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Yong Min Huh | - |
dc.contributor.googleauthor | Ji Hoon Jeong | - |
dc.contributor.googleauthor | Tae Gwan Park | - |
dc.contributor.googleauthor | Hyejung Mok | - |
dc.contributor.googleauthor | Sun Hwa Kim | - |
dc.identifier.doi | 10.1002/mabi.201300340 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02176 | - |
dc.identifier.eissn | 1616-5195 | - |
dc.identifier.pmid | 24634264 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201300340/abstract | - |
dc.subject.keyword | cell engineering | - |
dc.subject.keyword | cerebral ischemia model | - |
dc.subject.keyword | cross-linked iron oxide nanoparticles | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | mesenchymal stem cells | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 380 | - |
dc.citation.endPage | 389 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, Vol.14(3) : 380-389, 2014 | - |
dc.identifier.rimsid | 51219 | - |
dc.type.rims | ART | - |
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