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Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease.

Authors
 Ji E Lee  ;  Kyoo H Cho  ;  Sook K Song  ;  Hee Jin Kim  ;  Hye Sun Lee  ;  Young H Sohn  ;  Phil Hyu Lee 
Citation
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.85(1) : 7-16, 2014 
Journal Title
 JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY 
ISSN
 2093-0879 
Issue Date
2014
MeSH
Aged ; Attention/physiology ; Brain/pathology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/pathology* ; Cognitive Dysfunction/psychology* ; Cohort Studies ; Dementia/etiology ; Dementia/psychology ; Disease Progression ; Executive Function ; Female ; Humans ; Image Processing, Computer-Assisted ; Language Tests ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Memory/physiology ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/pathology* ; Parkinson Disease/psychology* ; Prospective Studies ; Psychomotor Performance/physiology ; Stroop Test
Keywords
Cognition ; Dementia ; Neuroanatomy ; Parkinson'S Disease
Abstract
BACKGROUND: Parkinson's disease with mild cognitive impairment (PD-MCI) is a heterogeneous entity in terms of cognitive profiles and conversion to dementia. However, the risk factors for ongoing cognitive decline in patients with PD-MCI are not clearly defined. METHODS: 51 patients with PD-MCI were prospectively followed-up for a minimum of 2 years. Subjects were classified as MCI converters (n=15) or MCI non-converters (n=36) based on whether they were subsequently diagnosed with PD dementia. We explored cognitive profiles and neuroanatomical characteristics of PD-MCI converters using voxel based morphometry (VBM) of grey matter (GM) density and region of interest based volumetric analysis of the substantia innominata (SI). RESULTS: PD-MCI converters showed more severe cognitive deficits in frontal executive functions, immediate verbal memory and visual recognition memory compared with PD-MCI non-converters. VBM analysis revealed that PD-MCI converters had significantly lower GM density in the left prefrontal areas, left insular cortex and bilateral caudate nucleus compared with that in PD-MCI non-converters. The mean normalised SI volume was significantly smaller in both PD-MCI converters (1.19±0.35, p<0.001) and PD-MCI non-converters (1.52±0.27, p<0.001) compared with that in controls (1.87±0.19). PD-MCI converters had a significantly smaller normalised SI volume than PD-MCI non-converters (p<0.001). CONCLUSIONS: Our data show that atrophy in the frontostriatal areas and cholinergic structures, as well as frontal lobe associated cognitive performance, may act as predictors of dementia in PD-MCI patients, suggesting distinctive patterns of cognitive profiles and a neuroanatomical basis for progressive PD-MCI.
Full Text
http://jnnp.bmj.com/content/85/1/7
DOI
10.1136/jnnp-2013-305062
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138891
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