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Exploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease.

DC FieldValueLanguage
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.contributor.author이혜선-
dc.contributor.author조규호-
dc.date.accessioned2015-12-28T11:11:25Z-
dc.date.available2015-12-28T11:11:25Z-
dc.date.issued2014-
dc.identifier.issn2093-0879-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138891-
dc.description.abstractBACKGROUND: Parkinson's disease with mild cognitive impairment (PD-MCI) is a heterogeneous entity in terms of cognitive profiles and conversion to dementia. However, the risk factors for ongoing cognitive decline in patients with PD-MCI are not clearly defined. METHODS: 51 patients with PD-MCI were prospectively followed-up for a minimum of 2 years. Subjects were classified as MCI converters (n=15) or MCI non-converters (n=36) based on whether they were subsequently diagnosed with PD dementia. We explored cognitive profiles and neuroanatomical characteristics of PD-MCI converters using voxel based morphometry (VBM) of grey matter (GM) density and region of interest based volumetric analysis of the substantia innominata (SI). RESULTS: PD-MCI converters showed more severe cognitive deficits in frontal executive functions, immediate verbal memory and visual recognition memory compared with PD-MCI non-converters. VBM analysis revealed that PD-MCI converters had significantly lower GM density in the left prefrontal areas, left insular cortex and bilateral caudate nucleus compared with that in PD-MCI non-converters. The mean normalised SI volume was significantly smaller in both PD-MCI converters (1.19±0.35, p<0.001) and PD-MCI non-converters (1.52±0.27, p<0.001) compared with that in controls (1.87±0.19). PD-MCI converters had a significantly smaller normalised SI volume than PD-MCI non-converters (p<0.001). CONCLUSIONS: Our data show that atrophy in the frontostriatal areas and cholinergic structures, as well as frontal lobe associated cognitive performance, may act as predictors of dementia in PD-MCI patients, suggesting distinctive patterns of cognitive profiles and a neuroanatomical basis for progressive PD-MCI.-
dc.description.statementOfResponsibilityopen-
dc.format.extent7~16-
dc.relation.isPartOfJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAttention/physiology-
dc.subject.MESHBrain/pathology-
dc.subject.MESHCognitive Dysfunction/etiology-
dc.subject.MESHCognitive Dysfunction/pathology*-
dc.subject.MESHCognitive Dysfunction/psychology*-
dc.subject.MESHCohort Studies-
dc.subject.MESHDementia/etiology-
dc.subject.MESHDementia/psychology-
dc.subject.MESHDisease Progression-
dc.subject.MESHExecutive Function-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHLanguage Tests-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMemory/physiology-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/pathology*-
dc.subject.MESHParkinson Disease/psychology*-
dc.subject.MESHProspective Studies-
dc.subject.MESHPsychomotor Performance/physiology-
dc.subject.MESHStroop Test-
dc.titleExploratory analysis of neuropsychological and neuroanatomical correlates of progressive mild cognitive impairment in Parkinson's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJi E Lee-
dc.contributor.googleauthorKyoo H Cho-
dc.contributor.googleauthorSook K Song-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1136/jnnp-2013-305062-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA03811-
dc.contributor.localIdA03312-
dc.contributor.localIdA03210-
dc.relation.journalcodeJ01623-
dc.identifier.eissn2093-0887-
dc.identifier.pmid23828835-
dc.identifier.urlhttp://jnnp.bmj.com/content/85/1/7-
dc.subject.keywordCognition-
dc.subject.keywordDementia-
dc.subject.keywordNeuroanatomy-
dc.subject.keywordParkinson'S Disease-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameCho, Kyoo H-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorCho, Kyoo Ho-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.rights.accessRightsfree-
dc.citation.volume85-
dc.citation.number1-
dc.citation.startPage7-
dc.citation.endPage16-
dc.identifier.bibliographicCitationJOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.85(1) : 7-16, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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