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Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea.

Authors
 Sook Hee Chung  ;  Soo Jung Park  ;  Hye Sun Lee  ;  Sung Pil Hong  ;  Jae Hee Cheon  ;  Tae Il Kim  ;  Won Ho Kim 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(45) : 17120-17126, 2014 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2014
MeSH
Adolescent ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/epidemiology ; Colitis, Ulcerative/genetics* ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/therapy ; Crohn Disease/diagnosis ; Crohn Disease/epidemiology ; Crohn Disease/genetics* ; Crohn Disease/immunology ; Crohn Disease/therapy ; Digestive System Surgical Procedures ; Disease Progression ; Female ; Gastrointestinal Agents/therapeutic use ; Genetic Predisposition to Disease ; Heredity ; Hospitalization ; Humans ; Male ; Middle Aged ; Pedigree ; Phenotype ; Recurrence ; Registries ; Remission Induction ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Young Adult
Keywords
Clinical characteristics ; Crohn’s disease ; Family history ; Inflammatory bowel disease ; Ulcerative colitis
Abstract
AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients. METHODS: We obtained clinical data on Crohn's disease (CD) (n = 691) and ulcerative colitis (n = 1113) from a tertiary referral medical center between 2005 and 2012. Seventeen patients (2.5%) with CD and 27 patients (2.4%) with ulcerative colitis (UC) were identified as having a familial history of IBD, including the first and second degree relatives. For each control case, three times the number of age-, sex-, and diagnosis year-matched CD and UC patients, without a family history of IBD, were randomly selected in this case control study. RESULTS: There were no significant differences in age or main symptom at diagnosis, extraintestinal manifestation, location/extent, behavior of disease activity, number of hospitalizations, number of operations, operation type, number of relapses, or oral medical treatment between familial and sporadic CD and UC patients. Median (min-max) follow-up periods after diagnosis of familial CD and sporadic CD patients were 84 (24-312) and 36 (8-240) mo, respectively (P = 0.008). Familial CD patients more frequently used anti-tumor necrosis factor (TNF) antibodies compared to sporadic CD patients (17.6% vs 0%, P = 0.014). CONCLUSION: In conclusion, a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients.
Files in This Item:
T201405467.pdf Download
DOI
10.3748/wjg.v20.i45.17120
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138684
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