Cited 16 times in
Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea.
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2015-12-28T11:05:48Z | - |
dc.date.available | 2015-12-28T11:05:48Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138684 | - |
dc.description.abstract | AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients. METHODS: We obtained clinical data on Crohn's disease (CD) (n = 691) and ulcerative colitis (n = 1113) from a tertiary referral medical center between 2005 and 2012. Seventeen patients (2.5%) with CD and 27 patients (2.4%) with ulcerative colitis (UC) were identified as having a familial history of IBD, including the first and second degree relatives. For each control case, three times the number of age-, sex-, and diagnosis year-matched CD and UC patients, without a family history of IBD, were randomly selected in this case control study. RESULTS: There were no significant differences in age or main symptom at diagnosis, extraintestinal manifestation, location/extent, behavior of disease activity, number of hospitalizations, number of operations, operation type, number of relapses, or oral medical treatment between familial and sporadic CD and UC patients. Median (min-max) follow-up periods after diagnosis of familial CD and sporadic CD patients were 84 (24-312) and 36 (8-240) mo, respectively (P = 0.008). Familial CD patients more frequently used anti-tumor necrosis factor (TNF) antibodies compared to sporadic CD patients (17.6% vs 0%, P = 0.014). CONCLUSION: In conclusion, a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 17120~17126 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use | - |
dc.subject.MESH | Colitis, Ulcerative/diagnosis | - |
dc.subject.MESH | Colitis, Ulcerative/epidemiology | - |
dc.subject.MESH | Colitis, Ulcerative/genetics* | - |
dc.subject.MESH | Colitis, Ulcerative/immunology | - |
dc.subject.MESH | Colitis, Ulcerative/therapy | - |
dc.subject.MESH | Crohn Disease/diagnosis | - |
dc.subject.MESH | Crohn Disease/epidemiology | - |
dc.subject.MESH | Crohn Disease/genetics* | - |
dc.subject.MESH | Crohn Disease/immunology | - |
dc.subject.MESH | Crohn Disease/therapy | - |
dc.subject.MESH | Digestive System Surgical Procedures | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Agents/therapeutic use | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Heredity | - |
dc.subject.MESH | Hospitalization | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pedigree | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/antagonists & inhibitors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Sook Hee Chung | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.3748/wjg.v20.i45.17120 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 25493025 | - |
dc.subject.keyword | Clinical characteristics | - |
dc.subject.keyword | Crohn’s disease | - |
dc.subject.keyword | Family history | - |
dc.subject.keyword | Inflammatory bowel disease | - |
dc.subject.keyword | Ulcerative colitis | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.citation.volume | 20 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 17120 | - |
dc.citation.endPage | 17126 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(45) : 17120-17126, 2014 | - |
dc.identifier.rimsid | 57342 | - |
dc.type.rims | ART | - |
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