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Ex vivo estimation of photoacoustic imaging for detecting thyroid microcalcifications.

Authors
 Jeeun Kang  ;  Woong Youn Chung  ;  Sang Wook Kang  ;  Hyeong Ju Kwon  ;  Jaeheung Yoo  ;  Eun Kyung Kim  ;  Jin Ho Chang  ;  Tai kyong Song  ;  Sohee Lee  ;  Jin Young Kwak 
Citation
 PLoS One, Vol.9(11) : e113358, 2014 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2014
MeSH
Adult ; Calcinosis/diagnosis* ; Calcinosis/diagnostic imaging ; Diagnostic Imaging/methods ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Image Enhancement/methods* ; Image Processing, Computer-Assisted/methods ; Male ; Middle Aged ; Photoacoustic Techniques/methods* ; Radiography ; Reproducibility of Results ; Sensitivity and Specificity ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology*
Abstract
BACKGROUND: The aim of this study was to evaluate the diagnostic utility of PAI at detecting thyroid microcalcifications at 700 nm laser wavelengths. METHODS: This study included 36 resected samples in 18 patients. To evaluate the PA manifestation of microcalcifications in PAI, gray level histogram and co-occurrence matrix (COM) texture parameters were extracted from the 3 fixed ROI US and PA images, respectively, per sample. We compared the textural parameters obtained from specimen PAIs between samples with punctate microcalcifications on specimen radiography and those without microcalcifications. RESULTS: On specimen US, the mean value (2748.4 ± 862.5) of samples with microcalcifications on specimen radiography was higher than that (1961.9 ± 780.2) of those without microcalcifications (P = 0.007). However, there were no significant differences in textural parameters obtained from specimen PAIs between samples with punctate microcalcifications on specimen radiography and those without when applying both the mean value of the three slices of thyroid specimens and the value of the thyroid specimen slice which had the highest value of the mean values in specimen US. CONCLUSION: PAI did not show significant PA contrast on thyroid microcalcifications indicating that the experimental setup and protocols should be enhanced, e.g., method of complete blood rejection from ex vivo specimens, the multi-wavelength spectroscopic PA imaging method which can solely extract the PA signal from microcalcifications even with high spectral interferences, or PA imaging with narrower slice thickness using 2-dimensional array transducer, etc.
Files in This Item:
T201404152.pdf Download
DOI
10.1371/journal.pone.0113358
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sang Wook(강상욱) ORCID logo https://orcid.org/0000-0001-5355-833X
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kwon, Hyeong Ju(권형주)
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Chung, Woung Youn(정웅윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138231
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