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Bone formation of intrabony defects in beagle dogs using calcium phosphate glass and glass-ceramics

Authors
 Seong Ho Choi  ;  D.H. Baik  ;  Yong Keun Lee  ;  Racquel Z. LeGeros  ;  Kwang Mahn Kim  ;  Kyoung Nam Kim  ;  Chong Kwan Kim  ;  C.S. Kim 
Citation
 Key Engineering Materials, Vol.284~286 : 957-960, 2005 
Journal Title
Key Engineering Materials
ISSN
 1013-9826 
Issue Date
2005
MeSH
Beagle Dog ; Bone ; Calcium Phosphate ; Glas Ceramics ; Glass ; Intrabony Defect
Keywords
Beagle Dog ; Bone ; Calcium Phosphate ; Glas Ceramics ; Glass ; Intrabony Defect
Abstract
The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass and glass-ceramics in the system of CaO-CaF2-P2O5-MgO-ZnO, which is already reported that promoted the bone-like tissue formation in vitro and formed new bone in Sprague-Dawley rats. We prepared calcium phosphate glass and glass-ceramics with Ca/P ratio of 0.6 using the system CaO-CaF2-P2O5-MgO-ZnO and subsequently milled to 400 µm. 4×4 mm 1-wall intrabony defects of six beagle dogs were surgically created and used in this study. 8 weeks after transplantation of the prepared calcium phosphate glass and glass-ceramics in the experimental group 1 and 2, respectively, the animals were sacrificed. No root resorption or ankylosis were observed in all groups. It can be examined that the prepared glass-ceramics were more effective in alveolar bone regeneration with statistical signigicant difference. In cementum regeneration, both the prepared glass and glass-ceramics showed significantly different effect. However, there were no statistical significant difference neither in glass nor glass-ceramics in the amounts of junctional epithelium migration and connective tissue adhesion. Further study is required to control the flowability as well as reduce the absorption rate in vivo.
Full Text
http://www.scientific.net/KEM.284-286.957
DOI
10.4028/www.scientific.net/KEM.284-286.957
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Yong Keun(이용근)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114838
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