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Eight-week histological analysis on the effect of chitosan on surgically created one-wall intrabony defects in beagle dogs

Authors
 Ji-Sook Park  ;  Seong-Ho Choi  ;  Chong-Kwan Kim  ;  Jung-Kiu Chai  ;  Kyoo-Sung Cho  ;  Ik-Sang Moon 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.30(5) : 443-453, 2003 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2003
MeSH
Alveolar Bone Loss/surgery* ; Alveolar Process/pathology* ; Animals ; Biopolymers/therapeutic use* ; Bone Regeneration/drug effects ; Bone Substitutes/therapeutic use* ; Chitin/analogs & derivatives* ; Chitin/therapeutic use* ; Chitosan ; Collagen/therapeutic use ; Connective Tissue/pathology ; Dental Cementum/pathology ; Disease Models, Animal ; Dogs ; Epithelial Attachment/pathology ; Male ; Mandible/surgery ; Maxilla/surgery ; Regeneration/drug effects ; Statistics, Nonparametric ; Surgical Flaps
Keywords
12716338
Abstract
OBJECTIVE: To evaluate the periodontal tissue regenerative effects of a chitosan/collagen sponge applied to preclinical one-wall intrabony defects surgically created in beagle dogs. MATERIAL AND METHODS: 4 x 4 mm one-wall intrabony defects were surgically created in the bilateral maxillary first and third, and the mandibular second and fourth premolars. The surgical control group received a flap operation only, while the buffer control group was treated afterwards with a phosphate-buffered saline/collagen sponge (CS) and the chitosan group was treated with a chitosan/cs. The subjects were killed 8 weeks after the operation, and a comparative histological examination was performed. RESULTS: The amount of junctional epithelium migration was 2.30+/-1.24 mm in the surgical control group, 1.49+/-1.25 mm in the buffer control group, and 0.26+/-0.59 mm in the chitosan group. A significant difference was exhibited only between the surgical control and the chitosan group (p<0.05). The amount of connective tissue adhesion was 0.68+/-0.60, 1.07+/-0.91, and 0.41+/-0.42 mm in the surgical control, buffer control, and the chitosan group, respectively. The amount of cementum regeneration was 1.42+/-0.49, 1.60+/-0.41, and 3.46+/-0.78 mm in the surgical control, buffer control, and the chitosan group, respectively. A significant difference was seen between the chitosan group and the rest (p<0.01). The amount of alveolar bone regeneration was 1.00+/-0.77, 1.52+/-0.37, and 2.43+/-0.44 mm in the surgical control, buffer control, and the chitosan group, respectively. A significant difference was observed between the chitosan group and the rest (p<0.05). CONCLUSION: The results demonstrate the beneficial effect of the chitosan/cs on the one-wall intrabony defects of beagle dogs. The inhibited apical migration of epithelium and the increase in the amount of new bone and new cementum suggest the potency of chitosan in inducing periodontal tissue regeneration.
Full Text
http://onlinelibrary.wiley.com/doi/10.1034/j.1600-051X.2003.10283.x/abstract
DOI
OAK-2003-00001
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Ik Sang(문익상)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113161
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