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원발성 소세포폐암에서 염색체 16번의 단완에 위치한 종양억제유전자좌의 확인

Other Titles
 Identification of Tumor Suppressor Loci on the Short Arm of Chromosome 16 in Primary Small Cell Lung Cancers 
Authors
 기현정  ;  신주혜  ;  김세규  ;  곽승민  ;  김성규  ;  장윤수  ;  김영삼  ;  신동환  ;  정경영  ;  장준 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.55(6) : 597-611, 2003 
Journal Title
 TUBERCULOSIS AND RESPIRATORY DISEASES 
ISSN
 0378-006 
Issue Date
2003
MeSH
Small cell lung cancer ; Chromosome 16 ; LOH ; Tumor suppressor
Keywords
Small cell lung cancer ; Chromosome 16 ; LOH ; Tumor suppressor
Abstract
Background : Loss of the short arm of chromosome 16 is a frequent event in various cancers, which suggests the presence of tumor suppressor gene(s) there. To map precise tumor suppressor loci on the chromosome arm for further positional cloning efforts, we tested 23 primary small cell lung cancers. Method : The DNAs extracted from paraffin embedded tissue blocks with primary tumor and corresponding control tissue were investigated. Twenty polymorphic microsatellite markers located in the short arm of chromosome 16 were used in the microsatellite analysis. Results : We found that six (26.1%) of 23 tumors exhibited LOH in at least one of tested microsatellite markers. Two (8.7%) of 6 tumors exhibiting LOH lost a larger area in chromosome 16p. LOH was observed in five common deleted regions at 16p. Among those areas, LOH between D16S668 and D16S749 was most frequent (21.1%). LOH was also observed at four other regions, between D16S3024 and D16S748, D16S405, D16S420, and D16S753. Six of 23 tumors exhibited shifted bands in at least one of the tested microsatellite markers. Shifted bands occurred in 3.3% (15 of 460) of the loci tested. Conclusion : Our data demonstrated that at least five tumor suppressor loci might exist in the short arm of chromosome 16 and that they may play an important role in small cell lung cancer tumorigenesis.
Files in This Item:
T200401505.pdf Download
DOI
OAK-2004-01246
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Seung Min(곽승민)
Kee, Hyun Jung(기현정) ORCID logo https://orcid.org/0000-0003-4350-1852
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Shin, Dong Hwan(신동환)
Shin, Ju Hye(신주혜)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112640
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