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자발성 세균성 복막염 환자에서 치료 경과에 따른 복수 Nitric oxide(NO)의 변화

Other Titles
 Changes of Ascites Nitric Oxide According to the Treatment Course in Cirrhotic Patients with Spontaneous Bacterial Peritonitis 
Authors
 박영수  ;  전재윤  ;  문영명  ;  한광협  ;  홍시내  ;  안상훈  ;  송시영  ;  백용한  ;  김혜영 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.10(3) : 207-215, 2004 
Journal Title
 Korean Journal of Hepatology (대한간학회지) 
ISSN
 1738-222X 
Issue Date
2004
MeSH
Adult ; Anti-Bacterial Agents/therapeutic use ; Ascitic Fluid/chemistry* ; Bacterial Infections/complications ; Bacterial Infections/drug therapy* ; Cefotaxime/therapeutic use ; Female ; Humans ; Liver Cirrhosis/complications* ; Male ; Middle Aged ; Nitric Oxide/analysis* ; Peritonitis/complications ; Peritonitis/drug therapy* ; Prognosis
Keywords
Liver cirrhosis ; Spontaneous bacterial peritonitis ; Ascites ; Nitric oxide
Abstract
Background/Aims: Nitricoxide (NO) is a molecule involved in vascular dilatation and pathogen suppression. It also has immunologic and regulatory functions. Liver cirrhosis is characterized by an increased risk for bacterial infections, including spontaneous bacterial peritonitis (SBP). The role of NO in SBP which develops in cirrhosis has not been clearly established. The aim of this study was to investigate the role of NO in the pathogenesis of SBP and its clinical usefulness for prediction of disease prognosis. Methods: This study was designed to investigate the changes of ascites NO in the course of treatment. Nitricoxide metabolite (nitrites+nitrates [NO x]) was measured by chemilum inescence in 84 ascites samples obtained from 84 cirrhotic patients. Among them , the 38 patients with SBP were treated with cefotaxim e 2.0 g, q 12hr for 7 days. In 24 of SBP patients, ascites was obtained consecutively before treatment (day 0),during treatment (day 2),and after treatment (day 7). Results: Ascites NO levels in the patients w ith SBP (n=38; 82.3 14.4 μM ) were not different from those in patients with sterile ascites (n=46; 54.6 13.0 μM ). There was no significant change of NO levels in sequential ascites samples during antibiotic treatment. A scites NO level before treatment was significantly higher in SBP patients who responded to antibiotics (n=26; 101.86 μM/L) than that in SBP patients who did not respond to antibiotics (n=12; 40.03 μM/L, P =0.044). A significant direct correlation was found between ascites and serum NO levels before treatment (Pearson correlation,r2=0.86,P =0.001). Among the SBP patients, treatment response rate to antibiotics were significantly higher in those patients with pretreatment NO level≥80 μM/L in multivariate analysis. Conclusions: Ascites NO level was not different between ascites from SBP patients and ascites from cirrhotic patients with sterile ascites. There were no changes of ascites NO in SBP patients during treatment. Therefore ascites NO was not useful to predict the progress of SBP. Ascites NO levels reflect serum NO levels, and the patients with higher NO level may have better response to antibiotics.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Young(김혜영)
Park, Young Soo(박영수)
Paik, Yong Han(백용한)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
Hong, Sinae(홍시내)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112231
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