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미숙아 대동맥 혈전의 Urokinase 투여 효과

Other Titles
 Urokinase Treatment for Aortic Thrombus in Preterm Infants 
 김경원  ;  이동우  ;  김명준  ;  이철  ;  박민수  ;  남궁란 
 Journal of the Korean Society of Neonatology (대한신생아학회지), Vol.11(2) : 203-209, 2004 
Journal Title
 Journal of the Korean Society of Neonatology (대한신생아학회지) 
Issue Date
Urokinase ; Aortic thrombus ; Preterm infant
Purpose : Aortic thrombus is a rare but serious complication in neonates, usually associated with central vessel catheterization. Currently treatment of asymptomatic aortic thrombus in preterm infants is controversial. We evaluated effects of urokinase in preterm infants with aortic thrombi. Methods : We studied 12 preterm infants in whom umbilical arterial catheterizations were performed and subsequently aortic thrombi were detected. In six patients bolus doses of urokinase 4,400 IU/kg were injected, followed by continuous infusions of 4,400 IU/kg/hr. The mean duration of urokinase use was 11 days (6-13 days). The other six patients who did not receive urokinase served as controls. The two groups were compared for changes in the size of thrombi. Results : The initial sizes of aortic thrombi upon detection were similar, although the diagnoses were made earlier in urokinase group than in controls. The days to 50% reduction in size of thrombi were significantly shorter in urokinase group, as were the days to complete resolution. One infant in urokinase group and 2 infants in control group had persistent aortic thrombi up to 90 days of follow-up. Intracranial hemorrhage and disseminated intravascular coagulopathy were absent in all 12 cases. Conclusion : Urokinase administration could be an effective therapy for preterm neonates with aortic thrombi. It significantly reduces the size of the thrombus and shortens the days to complete resolution.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Lee, Chul(이철)
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