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Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study

 Hye Won Chung  ;  Seung Woo Park  ;  Si Young Song  ;  Sung Hoon Noh  ;  Woo Jin Hyung  ;  Han-Soo Kim  ;  Ju Won Kim  ;  Jin Kyung Kang  ;  Jae Bock Chung 
 ONCOLOGY REPORTS, Vol.12(1) : 33-39, 2004 
Journal Title
Issue Date
Adenocarcinoma/genetics* ; Adult ; Age Factors ; Aged ; DNA Primers ; Female ; Gene Expression Profiling* ; Humans ; Male ; Neoplasm Proteins/genetics ; Oligonucleotide Array Sequence Analysis* ; RNA, Neoplasm/genetics ; RNA, Neoplasm/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach Neoplasms/genetics*
In the current study, we compared the differential expression profiles of genes affected by endocrine disruptor in gastric carcinomas of the young and old using cDNA microarray. Five gastric carcinoma tissues of young patients (≤35 years) were compared with 5 disease-free gastric tissues of age-matched healthy young people (experiment 1) and 5 gastric carcinoma tissues of old patients (≥65 years) (experiment 2), respectively. We hybridized the tissues with IntelliGene™ Human DNA Chip for endocrine disruption study, and identified finally the results common to the two experiments. Of the 220 genes represented on the array, 6 genes were up-regulated and 3 genes were down-regulated in the gastric carcinomas of young patients compared with those of old patients and those of the young volunteers. In conclusion, the genes affected by endocrine disruptors were differently expressed in young-age gastric carcinoma versus the old-age gastric carcinoma. So, we suggest that the gastric carcinoma in the young is the result of a genetic background that differs from that of the old and endocrine disruptors may play an important role in the carcinogenesis of gastric carcinoma in the young.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Han Soo(김한수)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
Chung, Hye Won(정혜원)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
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