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Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study

DC FieldValueLanguage
dc.contributor.author김한수-
dc.contributor.author노성훈-
dc.contributor.author박승우-
dc.contributor.author송시영-
dc.contributor.author정재복-
dc.contributor.author정혜원-
dc.contributor.author형우진-
dc.date.accessioned2015-07-14T16:51:37Z-
dc.date.available2015-07-14T16:51:37Z-
dc.date.issued2004-
dc.identifier.issn1021-335X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111733-
dc.description.abstractIn the current study, we compared the differential expression profiles of genes affected by endocrine disruptor in gastric carcinomas of the young and old using cDNA microarray. Five gastric carcinoma tissues of young patients (≤35 years) were compared with 5 disease-free gastric tissues of age-matched healthy young people (experiment 1) and 5 gastric carcinoma tissues of old patients (≥65 years) (experiment 2), respectively. We hybridized the tissues with IntelliGene™ Human DNA Chip for endocrine disruption study, and identified finally the results common to the two experiments. Of the 220 genes represented on the array, 6 genes were up-regulated and 3 genes were down-regulated in the gastric carcinomas of young patients compared with those of old patients and those of the young volunteers. In conclusion, the genes affected by endocrine disruptors were differently expressed in young-age gastric carcinoma versus the old-age gastric carcinoma. So, we suggest that the gastric carcinoma in the young is the result of a genetic background that differs from that of the old and endocrine disruptors may play an important role in the carcinogenesis of gastric carcinoma in the young.-
dc.description.statementOfResponsibilityopen-
dc.format.extent33~39-
dc.relation.isPartOfONCOLOGY REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHDNA Primers-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeoplasm Proteins/genetics-
dc.subject.MESHOligonucleotide Array Sequence Analysis*-
dc.subject.MESHRNA, Neoplasm/genetics-
dc.subject.MESHRNA, Neoplasm/isolation & purification-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.titleDifferences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHye Won Chung-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorHan-Soo Kim-
dc.contributor.googleauthorJu Won Kim-
dc.contributor.googleauthorJin Kyung Kang-
dc.contributor.googleauthorJae Bock Chung-
dc.identifier.doi10.3892/or.12.1.33-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02419-
dc.identifier.eissn1791-2431-
dc.identifier.pmid15201955-
dc.identifier.urlhttp://www.spandidos-publications.com/or/12/1/33-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.alternativeNameChung, Hye Won-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.rights.accessRightsnot free-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage33-
dc.citation.endPage39-
dc.identifier.bibliographicCitationONCOLOGY REPORTS, Vol.12(1) : 33-39, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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