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Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis

Authors
 Kyung Yul Lee  ;  Eun Hee Kim  ;  Ji Hoe Heo  ;  Byung In Lee  ;  Sang-Nae Cho  ;  Hyunjeong Ryu  ;  Won Seok Yang 
Citation
 Journal of the Neurological Sciences, Vol.220(1-2) : 73-78, 2004 
Journal Title
 Journal of the Neurological Sciences 
ISSN
 0022-510X 
Issue Date
2004
Abstract
Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022510X04000371
DOI
10.1016/j.jns.2004.02.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Hyunjeong(류현정)
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Lee, Byung In(이병인)
Cho, Sang Nae(조상래)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111598
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