Cited 46 times in
Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류현정 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2015-07-14T16:47:32Z | - |
dc.date.available | 2015-07-14T16:47:32Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111598 | - |
dc.description.abstract | Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~78 | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel/methods | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 2/cerebrospinal fluid* | - |
dc.subject.MESH | Matrix Metalloproteinase 9/cerebrospinal fluid* | - |
dc.subject.MESH | Meningitis, Aseptic/cerebrospinal fluid | - |
dc.subject.MESH | Meningitis, Aseptic/enzymology | - |
dc.subject.MESH | Tuberculosis, Meningeal/cerebrospinal fluid* | - |
dc.subject.MESH | Tuberculosis, Meningeal/enzymology | - |
dc.title | Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Kyung Yul Lee | - |
dc.contributor.googleauthor | Eun Hee Kim | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Hyunjeong Ryu | - |
dc.contributor.googleauthor | Won Seok Yang | - |
dc.identifier.doi | 10.1016/j.jns.2004.02.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01897 | - |
dc.identifier.eissn | 1878-5883 | - |
dc.identifier.pmid | 15140609 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022510X04000371 | - |
dc.subject.keyword | Metalloproteinase | - |
dc.subject.keyword | Tuberculous meningitis | - |
dc.subject.keyword | Aseptic meningitis | - |
dc.subject.keyword | Cerebrospinal fluid | - |
dc.subject.keyword | ELISA | - |
dc.subject.keyword | Zymography | - |
dc.contributor.alternativeName | Ryu, Hyunjeong | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 220 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.220(1-2) : 73-78, 2004 | - |
dc.identifier.rimsid | 37354 | - |
dc.type.rims | ART | - |
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