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Periodontal Repair in Surgically Created Intrabony Defects in Dogs: Influence of the Number of Bone Walls on Healing Response

 Chang-Sung Kim  ;  Seong-Ho Choi  ;  Chong-Kwan Kim  ;  Ulf M.E. Wikesjö  ;  Ik-Sang Moon  ;  Kyoo-Sung Cho  ;  Jung-Kiu Chai 
 JOURNAL OF PERIODONTOLOGY, Vol.75(2) : 229-235, 2004 
Journal Title
Issue Date
Alveolar Bone Loss/pathology* ; Alveolar Bone Loss/surgery ; Alveolar Process/pathology ; Alveolectomy ; Animals ; Bone Regeneration/physiology ; Dental Cementum/pathology ; Dogs ; Epithelial Attachment/pathology ; Mandible/pathology ; Mandible/surgery ; Regeneration/physiology ; Surgical Flaps/pathology ; Tooth Cervix/pathology ; Tooth Root/pathology ; Treatment Outcome ; Wound Healing/physiology
Animal studies ; periodontal diseases/surgery ; periodontal regeneration ; surgical flaps ; wound healing
BACKGROUND: The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration. METHODS: One-, 2-, and 3-wall intrabony periodontal defects were surgically produced at the proximal aspect of mandibular premolars in either right or left jaw quadrants in six beagle dogs. Mucoperiosteal flaps were positioned and sutured to their presurgery position following defect preparation. The animals were euthanized at 8 weeks post-surgery, and block sections of the defect sites were collected for histologic and histometric analysis. RESULTS: Bone and cementum regeneration was positively correlated to the number of bone walls limiting the intrabony periodontal defects. The junctional epithelium averaged (+/- SD) 1.5 +/- 0.2, 1.2 +/- 0.3, and 0.9 +/- 0.2 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). Cementum regeneration averaged 1.2 +/- 0.6, 2.0 +/- 0.6, and 2.8 +/- 0.5 mm for the 1-, 2-, and 3-wall defects, respectively; all groups were significantly different from each other (P <0.05). Bone regeneration averaged 1.5 +/- 0.5, 1.7 +/- 0.6, and 2.3 +/- 0.5 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). CONCLUSIONS: The results suggest that the number of bone walls is a critical factor determining treatment outcomes in intrabony periodontal defects. One- and 3-wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Moon, Ik Sang(문익상)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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