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Lack of Correlation Between P-glycoprotein and Chemotherapy Resistance in Nasal NK/T-cell Lymphomas

 Gwi Eon Kim  ;  Woo-Ick Yang  ;  Jee-Sook Hahn  ;  Jae Kyung Roh  ;  Nae Choon Yoo  ;  Chang Ok Suh  ;  Jae Ho Cho  ;  Joo Hang Kim  ;  Hyun Cheol Chung  ;  Sun Young Rha  ;  Sang-Wook Lee 
 LEUKEMIA & LYMPHOMA, Vol.45(9) : 1857-1864, 2004 
Journal Title
Issue Date
ATP Binding Cassette Transporter, Subfamily B, Member 1/immunology ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism* ; Adult ; Aged ; DrugResistance, Neoplasm* ; Female ; Humans ; Immunohistochemistry ; Killer Cells, Natural/pathology* ; Lymphoma,T-Cell/drug therapy* ; Lymphoma,T-Cell/metabolism* ; Lymphoma,T-Cell/mortality ; Lymphoma,T-Cell/pathology ; Male ; Middle Aged ; Prognosis ; Survival Rate
MDR ; NK/T-cell lymphomas ; P-glycorprotein
Thirty patients with nasal natural killer (NK)/T-cell lymphoma, who underwent systemic chemotherapy with or without involved-field radiotherapy between 1993 and 1998, were retrospectively reviewed to determine the clinical significance of P-glycoprotein immunohistochemically identified in tumor specimens. Eighty percent of previously untreated patients expressed P-glycoprotein. According to P-glycoprotein immunoreactivity, all patients with nasal NK/T-cell lymphoma were divided into 2 groups; (a) P-glycoprotein-negative group (N = 6) and (b) P-glycoprotein-positive group (N = 24). There was no significant difference in clinical profiles between both groups. Regardless of the P-glycoprotein expressions, Epstein-Barr virus genomes were almost identically detected in patients of the 2 groups. Contrary to our expectations, however, P-glycoprotein expressions were not found to be a strong predictor of chemotherapy resistance. Although 2 (33%) of 6 P-glycoprotein-negative patients and 10 (42%) of the 24 P-glycoprotein-positive patients showed a favorable response to systemic chemotherapy, 4 (67%) of 6 P-glycoprotein-negative patients did not achieve complete response (CR) to chemotherapy, which led to an early death, whereas 4 (17%) of the 24 P-glycoprotein-positive patients achieved CR to chemotherapy despite positive P-glycoprotein immunoreactivity. Overall, there were no significant differences in either CR rate or the response rate of patients in the two groups. Overall 5-year actuarial survival and disease-free survival for all patients were 44% and 47%, respectively, but no differences in survival rates were observed between 2 groups. (5-year actuarial survival rate: 33% for the P-glycoprotein-negative, 50% for the P-glycoprotein-positive) (P = 0.7093, log-rank). On univariate and multivariate analyses, P-glycoprotein expressions by immunohistochemical study were not found to be an important prognostic factor. Given these observations, we conclude that the molecular mechanisms of resistance to chemotherapy in nasal NK/T-cell lymphoma patients are not entirely dependent on P-glycoprotein, and that other complex mechanisms of drug action and resistance may be likely to be involved.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Suh, Chang Ok(서창옥)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Yoo, Nae Choon(유내춘)
Lee, Sang Wook(이상욱)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Hahn, Jee Sook(한지숙)
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