Cited 17 times in
Lack of Correlation Between P-glycoprotein and Chemotherapy Resistance in Nasal NK/T-cell Lymphomas
DC Field | Value | Language |
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dc.contributor.author | 김귀언 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 유내춘 | - |
dc.contributor.author | 이상욱 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 한지숙 | - |
dc.date.accessioned | 2015-07-14T16:35:21Z | - |
dc.date.available | 2015-07-14T16:35:21Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111194 | - |
dc.description.abstract | Thirty patients with nasal natural killer (NK)/T-cell lymphoma, who underwent systemic chemotherapy with or without involved-field radiotherapy between 1993 and 1998, were retrospectively reviewed to determine the clinical significance of P-glycoprotein immunohistochemically identified in tumor specimens. Eighty percent of previously untreated patients expressed P-glycoprotein. According to P-glycoprotein immunoreactivity, all patients with nasal NK/T-cell lymphoma were divided into 2 groups; (a) P-glycoprotein-negative group (N = 6) and (b) P-glycoprotein-positive group (N = 24). There was no significant difference in clinical profiles between both groups. Regardless of the P-glycoprotein expressions, Epstein-Barr virus genomes were almost identically detected in patients of the 2 groups. Contrary to our expectations, however, P-glycoprotein expressions were not found to be a strong predictor of chemotherapy resistance. Although 2 (33%) of 6 P-glycoprotein-negative patients and 10 (42%) of the 24 P-glycoprotein-positive patients showed a favorable response to systemic chemotherapy, 4 (67%) of 6 P-glycoprotein-negative patients did not achieve complete response (CR) to chemotherapy, which led to an early death, whereas 4 (17%) of the 24 P-glycoprotein-positive patients achieved CR to chemotherapy despite positive P-glycoprotein immunoreactivity. Overall, there were no significant differences in either CR rate or the response rate of patients in the two groups. Overall 5-year actuarial survival and disease-free survival for all patients were 44% and 47%, respectively, but no differences in survival rates were observed between 2 groups. (5-year actuarial survival rate: 33% for the P-glycoprotein-negative, 50% for the P-glycoprotein-positive) (P = 0.7093, log-rank). On univariate and multivariate analyses, P-glycoprotein expressions by immunohistochemical study were not found to be an important prognostic factor. Given these observations, we conclude that the molecular mechanisms of resistance to chemotherapy in nasal NK/T-cell lymphoma patients are not entirely dependent on P-glycoprotein, and that other complex mechanisms of drug action and resistance may be likely to be involved. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1857~1864 | - |
dc.relation.isPartOf | LEUKEMIA & LYMPHOMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Subfamily B, Member 1/immunology | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | DrugResistance, Neoplasm* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Killer Cells, Natural/pathology* | - |
dc.subject.MESH | Lymphoma,T-Cell/drug therapy* | - |
dc.subject.MESH | Lymphoma,T-Cell/metabolism* | - |
dc.subject.MESH | Lymphoma,T-Cell/mortality | - |
dc.subject.MESH | Lymphoma,T-Cell/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Lack of Correlation Between P-glycoprotein and Chemotherapy Resistance in Nasal NK/T-cell Lymphomas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Woo-Ick Yang | - |
dc.contributor.googleauthor | Jee-Sook Hahn | - |
dc.contributor.googleauthor | Jae Kyung Roh | - |
dc.contributor.googleauthor | Nae Choon Yoo | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.contributor.googleauthor | Jae Ho Cho | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Sang-Wook Lee | - |
dc.identifier.doi | 10.1080/10428190410001693524 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02457 | - |
dc.contributor.localId | A02823 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04327 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J02165 | - |
dc.identifier.eissn | 1029-2403 | - |
dc.identifier.pmid | 15223647 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/10428190410001693524 | - |
dc.subject.keyword | MDR | - |
dc.subject.keyword | NK/T-cell lymphomas | - |
dc.subject.keyword | P-glycorprotein | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoo, Nae Choon | - |
dc.contributor.alternativeName | Lee, Sang Wook | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoo, Nae Choon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Wook | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1857 | - |
dc.citation.endPage | 1864 | - |
dc.identifier.bibliographicCitation | LEUKEMIA & LYMPHOMA, Vol.45(9) : 1857-1864, 2004 | - |
dc.identifier.rimsid | 36199 | - |
dc.type.rims | ART | - |
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