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Protective Effect of Agmatine on a Reperfusion Model After Transient Cerebral Ischemia: Temporal Evolution on Perfusion MR Imaging and Histopathologic Findings

 D.J. Kim  ;  D.I. Kim  ;  S.K. Lee  ;  S.H. Suh  ;  Y.J. Lee  ;  J. Kim  ;  T.S. Chung  ;  J.E. Lee 
Journal Title
Issue Date
Agmatine/therapeutic use* ; Animals ; Cats ; Cerebrovascular Circulation ; Disease Models, Animal ; Ischemic Attack, Transient/drug therapy* ; Ischemic Attack, Transient/pathology* ; Ischemic Attack, Transient/physiopathology ; Magnetic Resonance Imaging* ; Time Factors
BACKGROUND AND PURPOSE: The goal of thrombolytic therapy in patients with acute ischemic stroke is early recanalization, but this may result in delayed reperfusion injury. The purpose of this study was to evaluate the neuroprotective effect of agmatine in a transient ischemic cat model by using MR perfusion imaging and histopathologic analyses. METHOD: One-hour temporary occlusion of the left middle cerebral artery of cats was performed in the control ischemia group (n = 10), and 100 mg/kg of agmatine was intravenously injected immediately after recanalization in the agmatine-treated group (n = 15). MR imaging was performed at 1, 24, and 48 hours after recanalization, and the perfusion patterns were investigated. Terminal-deoxynucleotidyl transferase mediated nick and end-labeling (TUNEL) and hematoxylin-eosin (H&E) stainings were performed at the corresponding sections. RESULTS: In the control ischemia group, the number of TUNEL-positive cells was significantly increased in the areas with reperfusion hyperemia (P < .05). In the agmatine-treated group, no significant increase in the number of TUNEL-positive cells was noted in the areas of reperfusion hyperemia. The difference in the number of TUNEL-positive cells between the control ischemia and agmatine-treated group in the areas of reperfusion hyperemia was significant (P < .05). The total number of TUNEL-positive cells and the area of severe ischemic neuronal damage on H&E stain were also significantly attenuated in the agmatine-treated cats compared with the control ischemia cats (P < .05). CONCLUSION: Our results suggest that agmatine has neuroprotective effects against reperfusion injury and ischemia.
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1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Chung, Tae Sub(정태섭)
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