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건성각결막염 환자에서 스테로이드 점안 후 눈물 신경성장인자의 변화

Other Titles
 Topical 0.1% Prednisolone Lowers Nerve Growth Factor Expression in Keratoconjunctivitis Sicca Patients 
Authors
 정승아  ;  이형근  ;  서경률  ;  홍순원  ;  김현창  ;  김응권 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.47(11) : 1720-1728, 2006 
Journal Title
 Journal of the Korean Ophthalmological Society  (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
2006
Abstract
Purpose: To compare nerve growth factor (NGF) levels in tears and on the ocular surface of normal controls with those of non-Sjogren type keratoconjunctivitis sicca (KCS) subjects, and investigate the effect of 0.1% prednisolone eye drops on NGF levels in KCS patients. Methods: Baseline tear NGF levels were measured in 41 KCS patients and 23 healthy control subjects using enzyme-linked immunosorbent assays (ELISA). KCS patients received 0.1% prednisolone drops in one eye, and 0.1% hyaluronic acid drops in the other eye, three times daily for 28 days. Impression cytology (IC) and immunostaining for NGF on conjunctival epithelium was performed for both groups. Results: KCS patients were found to have higher baseline tear NGF concentrations compared to age-and sex-matched healthy control subjects (65.9±14.5 vs. 122.1±45.3, p<0.0001). In KCS patients, prednisolone treatment for 28 days resulted in a decrease in tear NGF levels, symptom scores and IC scores, whereas hyaluronic acid treatment had no such effect (68.2±25.0 pg/μg vs. 108.0±43.4 pg/μg, p<0.0001 for tear NGF/TP ratio; 2.16±1.01 vs. 3.39±1.50, p=0.0014 for symptom scale; 1.05±0.67 vs. 1.61±0.86, p=0.0317 for IC). Measurements taken at both 14 and 28 days indicate that neither prednisolone nor hyaluronic acid treatment affected BUT or Schirmer values. Conclusions: KCS patients showed elevated levels of tear NGF, which were decreased by treatment with 0.1% prednisolone. These data suggest that the ocular surface NGF may play an important role in ocular surface inflammation processes associated with dry eyes.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Chung, Seung Ah(정승아)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110756
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