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건성각결막염 환자에서 스테로이드 점안 후 눈물 신경성장인자의 변화

DC Field Value Language
dc.contributor.author김응권-
dc.contributor.author김현창-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author정승아-
dc.contributor.author홍순원-
dc.date.accessioned2015-06-10T12:57:34Z-
dc.date.available2015-06-10T12:57:34Z-
dc.date.issued2006-
dc.identifier.issn0378-6471-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110756-
dc.description.abstractPurpose: To compare nerve growth factor (NGF) levels in tears and on the ocular surface of normal controls with those of non-Sjogren type keratoconjunctivitis sicca (KCS) subjects, and investigate the effect of 0.1% prednisolone eye drops on NGF levels in KCS patients. Methods: Baseline tear NGF levels were measured in 41 KCS patients and 23 healthy control subjects using enzyme-linked immunosorbent assays (ELISA). KCS patients received 0.1% prednisolone drops in one eye, and 0.1% hyaluronic acid drops in the other eye, three times daily for 28 days. Impression cytology (IC) and immunostaining for NGF on conjunctival epithelium was performed for both groups. Results: KCS patients were found to have higher baseline tear NGF concentrations compared to age-and sex-matched healthy control subjects (65.9±14.5 vs. 122.1±45.3, p<0.0001). In KCS patients, prednisolone treatment for 28 days resulted in a decrease in tear NGF levels, symptom scores and IC scores, whereas hyaluronic acid treatment had no such effect (68.2±25.0 pg/μg vs. 108.0±43.4 pg/μg, p<0.0001 for tear NGF/TP ratio; 2.16±1.01 vs. 3.39±1.50, p=0.0014 for symptom scale; 1.05±0.67 vs. 1.61±0.86, p=0.0317 for IC). Measurements taken at both 14 and 28 days indicate that neither prednisolone nor hyaluronic acid treatment affected BUT or Schirmer values. Conclusions: KCS patients showed elevated levels of tear NGF, which were decreased by treatment with 0.1% prednisolone. These data suggest that the ocular surface NGF may play an important role in ocular surface inflammation processes associated with dry eyes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1720~1728-
dc.relation.isPartOfJOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title건성각결막염 환자에서 스테로이드 점안 후 눈물 신경성장인자의 변화-
dc.title.alternativeTopical 0.1% Prednisolone Lowers Nerve Growth Factor Expression in Keratoconjunctivitis Sicca Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthor정승아-
dc.contributor.googleauthor이형근-
dc.contributor.googleauthor서경률-
dc.contributor.googleauthor홍순원-
dc.contributor.googleauthor김현창-
dc.contributor.googleauthor김응권-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.contributor.localIdA01142-
dc.contributor.localIdA01870-
dc.contributor.localIdA03303-
dc.contributor.localIdA03644-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ01838-
dc.identifier.eissn2092-9374-
dc.subject.keywordKeratoconjunctivitis sicca-
dc.subject.keywordNerve growth factor-
dc.subject.keywordPrednisolone-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.alternativeNameChung, Seung Ah-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.contributor.affiliatedAuthorChung, Seung Ah-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.rights.accessRightsfree-
dc.citation.volume47-
dc.citation.number11-
dc.citation.startPage1720-
dc.citation.endPage1728-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, Vol.47(11) : 1720-1728, 2006-
dc.identifier.rimsid54415-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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