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Alteration of hTERT full-length variant expression level showed different gene expression profiles and genomic copy number changes in breast cancer

 Sun Y. Rha  ;  Hei C. Jeung  ;  Woo I. Yang  ;  Jin J. Kim  ;  Tae J. Oh  ;  Sung W. An  ;  Hyun C. Chung 
 Oncology Reports, Vol.15(4) : 749-755, 2006 
Journal Title
 Oncology Reports 
Issue Date
We analyzed hTERT splicing patterns with respect to telomerase activity in breast cancer. Using a cDNA microarray in 22 cell lines, we observed the difference in expression profiling based on the different levels of full-length variant expression with 71 selected genes. Using 33 known genes that act with the telomerase complex, we performed unsupervised clustering with all cell lines, and found a clustering tendency related to the full-length variant expression level. Using array-based CGH, highly altered genomic copy number changes were found more often in MCF-7 (159 genes) than in MDA-MB-231 (109 genes) and MDA-MB-435 (49 genes), suggesting more genomic changes in MCF-7 cells. On comparing MCF-7 with MDA-MB231 and MDA-MB-435 cell lines, we identified 8 genes with different copy numbers, including dystroglycan, which is located in the p12-21.2 area of chromosome 3. In conclusion, alterations in the level of the full-length variant of hTERT showed different gene expression profiles and genomic copy number changes in breast cancer, which require further study into their cause-and-effect relationship.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
Yonsei Authors
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
안성환(An, Sung Whan)
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
정희철(Jeung, Hei Cheul) ORCID logo https://orcid.org/0000-0003-0952-3679
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