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Alteration of hTERT full-length variant expression level showed different gene expression profiles and genomic copy number changes in breast cancer

DC FieldValueLanguage
dc.contributor.author라선영-
dc.contributor.author안성환-
dc.contributor.author양우익-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2015-06-10T12:50:05Z-
dc.date.available2015-06-10T12:50:05Z-
dc.date.issued2006-
dc.identifier.issn1021-335X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110530-
dc.description.abstractWe analyzed hTERT splicing patterns with respect to telomerase activity in breast cancer. Using a cDNA microarray in 22 cell lines, we observed the difference in expression profiling based on the different levels of full-length variant expression with 71 selected genes. Using 33 known genes that act with the telomerase complex, we performed unsupervised clustering with all cell lines, and found a clustering tendency related to the full-length variant expression level. Using array-based CGH, highly altered genomic copy number changes were found more often in MCF-7 (159 genes) than in MDA-MB-231 (109 genes) and MDA-MB-435 (49 genes), suggesting more genomic changes in MCF-7 cells. On comparing MCF-7 with MDA-MB231 and MDA-MB-435 cell lines, we identified 8 genes with different copy numbers, including dystroglycan, which is located in the p12-21.2 area of chromosome 3. In conclusion, alterations in the level of the full-length variant of hTERT showed different gene expression profiles and genomic copy number changes in breast cancer, which require further study into their cause-and-effect relationship.-
dc.description.statementOfResponsibilityopen-
dc.format.extent749~755-
dc.relation.isPartOfONCOLOGY REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlternative Splicing/genetics-
dc.subject.MESHBreast Neoplasms/enzymology-
dc.subject.MESHBreast Neoplasms/genetics-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCell Line-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHChromosome Mapping-
dc.subject.MESHCluster Analysis-
dc.subject.MESHDNA-Binding Proteins/genetics*-
dc.subject.MESHDNA-Binding Proteins/metabolism-
dc.subject.MESHGene Dosage-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHGene Expression Regulation, Neoplastic/genetics-
dc.subject.MESHHCT116 Cells-
dc.subject.MESHHL-60 Cells-
dc.subject.MESHHeLa Cells-
dc.subject.MESHHumans-
dc.subject.MESHIsoenzymes/genetics-
dc.subject.MESHIsoenzymes/metabolism-
dc.subject.MESHOligonucleotide Array Sequence Analysis/methods-
dc.subject.MESHTelomerase/genetics*-
dc.subject.MESHTelomerase/metabolism-
dc.titleAlteration of hTERT full-length variant expression level showed different gene expression profiles and genomic copy number changes in breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSun Y. Rha-
dc.contributor.googleauthorHei C. Jeung-
dc.contributor.googleauthorWoo I. Yang-
dc.contributor.googleauthorJin J. Kim-
dc.contributor.googleauthorTae J. Oh-
dc.contributor.googleauthorSung W. An-
dc.contributor.googleauthorHyun C. Chung-
dc.identifier.doi10.3892/or.15.4.749-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02300-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.contributor.localIdA02239-
dc.relation.journalcodeJ02419-
dc.identifier.eissn1791-2431-
dc.identifier.pmid16525654-
dc.identifier.urlhttp://www.spandidos-publications.com/or/15/4/749-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameAn, Sung Whan-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorAn, Sung Whan-
dc.rights.accessRightsnot free-
dc.citation.volume15-
dc.citation.number4-
dc.citation.startPage749-
dc.citation.endPage755-
dc.identifier.bibliographicCitationONCOLOGY REPORTS, Vol.15(4) : 749-755, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers

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