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Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea

 Sang Hoon Ahn  ;  Do Young Kim  ;  Hye Young Chang  ;  Sun Pyo Hong  ;  Jeon-Soo Shin  ;  Yu Seun Kim  ;  Hyejin Kim  ;  Ja Kyung Kim  ;  Yong Han Paik  ;  Kwan Sik Lee  ;  Chae Yoon Chon  ;  Young Myoung Moon  ;  Kwang-Hyub Han 
 JOURNAL OF MEDICAL VIROLOGY, Vol.78(12) : 1564-1571, 2006 
Journal Title
Issue Date
Adult ; Carrier State/physiopathology ; Carrier State/virology ; Chemokine CCL5/genetics* ; Female ; Genetic Variation* ; Genotype ; Hepatitis B/genetics ; Hepatitis B/immunology* ; Hepatitis B/physiopathology ; Hepatitis B/virology* ; Hepatitis B virus/pathogenicity* ; Humans ; Korea ; Male ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Receptors, CCR5/genetics* ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
genetic polymorphism ; CCR5 ; RANTES ; hepatitis B virus
Immunogenetic factors may play a role in determining the susceptibility of an individual to viral infection. The aim of current study was to investigate the association of clearance of hepatitis B virus (HBV) with promoter polymorphisms within the CC chemokine receptor 5 (CCR5) and its major ligand, regulated upon activation, normal T cells expressed and secreted (RANTES) genes. Five chemokine system polymorphisms (CCR5 Δ32, CCR5 promoter 59029G/A, 59353C/T, RANTES −403G/A, and −28C/G) were studied in a total of 698 subjects. The carriage of each genetic variant was compared among “spontaneously recovered” group (n = 243), “chronic carrier” group (n = 349), and “unexposed” group (n = 106). CCR5 59029G promoter variant was associated with clearance of HBV infection in an acute phase (OR = 1.71, P = 0.006, dominant model; OR = 2.17, P < 0.001, recessive model) and amelioration of hepatic inflammation (P = 0.003) with the control of HBV replication (P = 0.04) in chronic carriers. Interestingly, CCR5 59029 was linked completely to CCR5 59353, and CCR5 Δ32 homozygosity or heterozygosity was not found in any Korean patient. No association was seen with RANTES polymorphisms at position −403 and −28. The CCR5 59029G/CCR5 59353T polymorphism may play a role in the clearance of HBV infection.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Paik, Yong Han(백용한)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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