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Inhibition of Apoptosis in Early Tooth Development Alters Tooth Shape and Size

Authors
 J.-Y. Kim  ;  Y.-G. Cha  ;  S.-W. Cho  ;  E.-J. Kim  ;  M.-J. Lee  ;  J.-M. Lee  ;  J. Cai  ;  H. Ohshima  ;  H.-S. Jung 
Citation
 JOURNAL OF DENTAL RESEARCH, Vol.85(6) : 530-535, 2006 
Journal Title
JOURNAL OF DENTAL RESEARCH
ISSN
 0022-0345 
Issue Date
2006
MeSH
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology* ; Caspase Inhibitors ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cysteine Proteinase Inhibitors/pharmacology ; Dental Enamel/growth & development ; Dental Enamel/pathology ; Embryo, Mammalian ; Mesoderm/drug effects ; Mesoderm/pathology ; Mice ; Mice, Inbred ICR ; Molar/growth & development ; Molar/pathology ; Odontogenesis/drug effects ; Odontogenesis/physiology* ; Odontometry ; Organ Culture Techniques ; Tooth Crown/growth & development ; Tooth Crown/pathology ; Tooth Germ/drug effects ; Tooth Germ/physiology* ; Tooth Germ/transplantation ; Transplantation, Isogeneic
Keywords
apoptosis ; tooth development ; tooth shape ; tooth size ; macrodontia
Abstract
Apoptosis plays important roles in various stages of organogenesis. In this study, we hypothesized that apoptosis would play an important role in tooth morphogenesis. We examined the role of apoptosis in early tooth development by using a caspase inhibitor, z-VAD-fmk, concomitant with in vitro organ culture and tooth germ transplantation into the kidney capsule. Inhibition of apoptosis at the early cap stage did not disrupt the cell proliferation level when compared with controls. However, the macroscopic morphology of mice molar teeth exhibited dramatic alterations after the inhibition of apoptosis. Crown height was reduced, and mesiodistal diameter was increased in a concentration-dependent manner with z-VAD-fmk treatment. Overall, apoptosis in the enamel knot would be necessary for the proper formation of molar teeth, including appropriate shape and size.
Full Text
http://jdr.sagepub.com/content/85/6/530.long
DOI
10.1177/154405910608500610
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Lee, Jong Min(이종민) ORCID logo https://orcid.org/0000-0002-9466-7644
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109644
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