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The Effect of Varying the Particle Size of Beta Tricalcium Phosphate Carrier of Recombinant Human Bone Morphogenetic Protein-4 on Bone Formation in Rat Calvarial Defects

Authors
 Ui-Won Jung  ;  Seong-Yong Choi  ;  Eun-Kyoung Pang  ;  Chang-Sung Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho 
Citation
 JOURNAL OF PERIODONTOLOGY, Vol.77(5) : 765-772, 2006 
Journal Title
JOURNAL OF PERIODONTOLOGY
ISSN
 0022-3492 
Issue Date
2006
MeSH
Animals ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins/therapeutic use* ; Bone Regeneration* ; Bone Substitutes/chemistry ; Bone Substitutes/therapeutic use* ; Calcium Phosphates/chemistry ; Calcium Phosphates/therapeutic use* ; Drug Carriers/chemistry* ; Humans ; Male ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/therapeutic use ; Skull/surgery*
Keywords
Beta tricalcium phosphate ; bone morphogenetic protein ; bone regeneration ; particle size ; porosity
Abstract
BACKGROUND: Beta tricalcium phosphate (beta-TCP) has been developed as one of the carriers of recombinant human bone morphogenetic protein (rhBMP). However, it is not known whether the particle size of beta-TCP is related to its resorption rate and the degree of bone formation. The purpose of this study was to evaluate the effect of using beta-TCP with different particle sizes on the ability of rhBMP-4 to enhance bone formation in the rat calvarial defect model.
METHODS: Calvarial, 8-mm-diameter, critical-size defects were created in 100 male Sprague-Dawley rats. Five groups of 20 animals each received either rhBMP-4 (2.5 microg) using beta-TCP with a particle size of 50 to 150 microm, rhBMP-4 (2.5 microg) using beta-TCP with a particle size of 150 to 500 microm, a beta-TCP control with a particle size of 50 to 150 microm, a beta-TCP control with a particle size of 150 to 500 microm, or a sham-surgery control, respectively, and were evaluated by measuring their histologic and histometric parameters following a 2- and 8-week healing interval.
RESULTS: There were no significant differences in the defect closure, new bone area, or augmented area between either the two rhBMP-4/beta-TCP groups or between the two beta-TCP control groups at 2 and 8 weeks.
CONCLUSIONS: rhBMP-4 combined with either small- or large-particle beta-TCP had a significant effect on the induction of bone formation compared to either a small- or large-particle beta-TCP control or a sham-surgery control. Within the parameters of this study, varying the particle size of beta-TCP did not seem to have a significant effect on bone formation.
Full Text
http://www.joponline.org/doi/abs/10.1902/jop.2006.050268
DOI
10.1902/jop.2006.050268
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109491
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