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The effect of a fibrin-fibronectin/β-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects

Authors
 Sung-Jae Hong  ;  Chang-Sung Kim  ;  Dong-Kwan Han  ;  Ik-Hyun Cho  ;  Ui-Won Jung  ;  Seong-Ho Choi  ;  Chong-Kwan Kim  ;  Kyoo-Sung Cho 
Citation
 BIOMATERIALS, Vol.27(20) : 3810-3816, 2006 
Journal Title
BIOMATERIALS
ISSN
 0142-9612 
Issue Date
2006
MeSH
Animals ; Biocompatible Materials/chemistry ; Biocompatible Materials/metabolism ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins/chemistry ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/metabolism* ; Calcium Phosphates/chemistry ; Calcium Phosphates/metabolism* ; Drug Carriers ; Fibrin/chemistry ; Fibrin/metabolism* ; Fibronectins/chemistry ; Fibronectins/metabolism* ; Humans ; Male ; Osteogenesis/physiology* ; Prostheses and Implants ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism* ; Skull/cytology ; Skull/pathology* ; Skull/physiology ; Transforming Growth Factor beta/chemistry ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism*
Keywords
Bone regeneration ; Carrier ; Bone morphogenetic protein-2 ; Carrier ; Fibrin-fibronectin sealing system ; β-tricalcium phosphate ; Rat calvarial defect model
Abstract
In spite of good prospects for bone morphogenetic proteins (BMP) applications, an ideal carrier system for BMPs has not yet been identified. The purpose of this study was to evaluate the osteogenic effect of a fibrin-fibronectin sealing system (FFSS) combined with beta-tricalcium phosphate (beta-TCP) as a carrier system for recombinant human bone morphogenetic proteins (rhBMP-2) in the rat calvarial defect model. Eight-millimeter critical-size calvarial defects were created in 100 male Sprague-Dawley rats. The animals were divided into five groups of 20 animals each. The defects were treated with rhBMP-2/FFSS, rhBMP-2/FFSS/beta-TCP, FFSS and FFSS/beta-TCP carrier control or were left untreated as a sham-surgery control. Defects were evaluated by histologic and histometric parameters following a 2- and 8-week healing interval (10 animals/group/healing intervals). The FFSS/beta-TCP carrier group was significantly greater in new bone area at 2 weeks (p<0.05) and new tissue area at 2 and 8 weeks (p<0.01) relative to the FFSS carrier group. New bone and new tissue area in the rhBMP-2/FFSS/beta-TCP group were significantly greater than in the rhBMP-2/FFSS group at 8 weeks (p<0.01). On histologic observation, FFSS remnants were observed at 2 weeks, but by 8 weeks, the FFSS appeared to be completely resorbed. rhBMP-2 combined with FFSS/beta-TCP produced significantly more new bone and new tissue formation in this calvarial defect model. In conclusion, FFSS/beta-TCP may be considered as an available carrier for rhBMP-2.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961206001815
DOI
10.1016/j.biomaterials.2006.02.045
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109486
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