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Characteristics of muscle fibers reconstituted in the regeneration process of masseter muscle in an mdx mouse model of muscular dystrophy

Authors
 Won-Hyung Lee  ;  Shinichi Abe  ;  Hee-Jin Kim  ;  Akinobu Usami  ;  Atsuro Honda  ;  Koji Sakiyama  ;  Yoshinobu Ide 
Citation
 JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, Vol.27(3-4) : 235-240, 2006 
Journal Title
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
ISSN
 0142-4319 
Issue Date
2006
MeSH
Animals ; Masseter Muscle/metabolism ; Masseter Muscle/physiology* ; Masseter Muscle/ultrastructure ; Mice ; Mice, Inbred mdx ; Muscle Fibers, Skeletal/metabolism* ; Muscular Dystrophies/metabolism* ; Muscular Dystrophy, Animal ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism* ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Regeneration*
Keywords
Myosin heavy chain ; MyHC2a ; MyHC2b ; Mdx ; LightCycler®
Abstract
Mdx mice, which lack dystrophin, were examined for changes in the properties of muscle fibers in the growth process of the masseter muscle at the morphological, protein and transcriptional levels. The slow-type isoform, MyHC-1, and the fast-type isoforms, MyHC-2a, MyHC-2d and MyHC-2b, were examined at the protein and the transcriptional level. Morphological examination showed that in the mdx mouse masseter muscle, degeneration, necrosis, and regeneration occurred, particularly at the age of 4 weeks, and many regenerated muscle fibers with centrally located nuclei were observed at the age of 9 weeks. The results of examination at the protein and the transcriptional level showed that in the process of muscle fiber degeneration, necrosis, and regeneration, the mdx mouse masseter muscle acquires muscle fiber characteristics entirely different from those in the normal mouse masseter muscle. In particular, MyHC-1, which is rarely found in normal mice, was very strongly expressed.
Full Text
http://link.springer.com/article/10.1007%2Fs10974-006-9066-5
DOI
10.1007/s10974-006-9066-5
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hee Jin(김희진) ORCID logo https://orcid.org/0000-0002-1139-6261
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109109
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