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Characteristics of muscle fibers reconstituted in the regeneration process of masseter muscle in an mdx mouse model of muscular dystrophy

DC Field Value Language
dc.contributor.author김희진-
dc.date.accessioned2015-06-10T12:03:20Z-
dc.date.available2015-06-10T12:03:20Z-
dc.date.issued2006-
dc.identifier.issn0142-4319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109109-
dc.description.abstractMdx mice, which lack dystrophin, were examined for changes in the properties of muscle fibers in the growth process of the masseter muscle at the morphological, protein and transcriptional levels. The slow-type isoform, MyHC-1, and the fast-type isoforms, MyHC-2a, MyHC-2d and MyHC-2b, were examined at the protein and the transcriptional level. Morphological examination showed that in the mdx mouse masseter muscle, degeneration, necrosis, and regeneration occurred, particularly at the age of 4 weeks, and many regenerated muscle fibers with centrally located nuclei were observed at the age of 9 weeks. The results of examination at the protein and the transcriptional level showed that in the process of muscle fiber degeneration, necrosis, and regeneration, the mdx mouse masseter muscle acquires muscle fiber characteristics entirely different from those in the normal mouse masseter muscle. In particular, MyHC-1, which is rarely found in normal mice, was very strongly expressed.-
dc.description.statementOfResponsibilityopen-
dc.format.extent235~240-
dc.relation.isPartOfJOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHMasseter Muscle/metabolism-
dc.subject.MESHMasseter Muscle/physiology*-
dc.subject.MESHMasseter Muscle/ultrastructure-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred mdx-
dc.subject.MESHMuscle Fibers, Skeletal/metabolism*-
dc.subject.MESHMuscular Dystrophies/metabolism*-
dc.subject.MESHMuscular Dystrophy, Animal-
dc.subject.MESHMyosin Heavy Chains/genetics-
dc.subject.MESHMyosin Heavy Chains/metabolism*-
dc.subject.MESHProtein Isoforms/genetics-
dc.subject.MESHProtein Isoforms/metabolism-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHRegeneration*-
dc.titleCharacteristics of muscle fibers reconstituted in the regeneration process of masseter muscle in an mdx mouse model of muscular dystrophy-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorWon-Hyung Lee-
dc.contributor.googleauthorShinichi Abe-
dc.contributor.googleauthorHee-Jin Kim-
dc.contributor.googleauthorAkinobu Usami-
dc.contributor.googleauthorAtsuro Honda-
dc.contributor.googleauthorKoji Sakiyama-
dc.contributor.googleauthorYoshinobu Ide-
dc.identifier.doi10.1007/s10974-006-9066-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01225-
dc.relation.journalcodeJ01613-
dc.identifier.eissn1573-2657-
dc.identifier.pmid16752197-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10974-006-9066-5-
dc.subject.keywordMyosin heavy chain-
dc.subject.keywordMyHC2a-
dc.subject.keywordMyHC2b-
dc.subject.keywordMdx-
dc.subject.keywordLightCycler®-
dc.contributor.alternativeNameKim, Hee Jin-
dc.contributor.affiliatedAuthorKim, Hee Jin-
dc.rights.accessRightsnot free-
dc.citation.volume27-
dc.citation.number3-4-
dc.citation.startPage235-
dc.citation.endPage240-
dc.identifier.bibliographicCitationJOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, Vol.27(3-4) : 235-240, 2006-
dc.identifier.rimsid50592-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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