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Delayed Hyperenhancement Magnetic Resonance Imaging Is Useful in Predicting Functional Recovery of Nonischemic Left Ventricular Systolic Dysfunction

Authors
 Sungha Park  ;  Byoung Wook Choi  ;  Se-Joong Rim  ;  Chi Young Shim  ;  Young-Guk Ko  ;  Seok-Min Kang  ;  Jong-Won Ha  ;  Yangsoo Jang  ;  Namsik Chung  ;  Kyu-Ok Choe  ;  Seung-Yun Cho 
Citation
 JOURNAL OF CARDIAC FAILURE, Vol.12(2) : 93-99, 2006 
Journal Title
JOURNAL OF CARDIAC FAILURE
ISSN
 1071-9164 
Issue Date
2006
MeSH
Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Dilated/physiopathology* ; Case-Control Studies ; Contrast Media ; Echocardiography, Doppler, Color ; Female ; Fibrosis ; Follow-Up Studies ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging, Cine* ; Male ; Middle Aged ; Myocardium/pathology* ; Predictive Value of Tests ; Recovery of Function/physiology* ; Sensitivity and Specificity ; Stroke Volume/physiology ; Systole/physiology ; Ventricular Dysfunction, Left/pathology ; Ventricular Dysfunction, Left/physiopathology*
Keywords
Cardiomyopathy ; magnetic resonance imaging ; echocardiography ; heart failure
Abstract
BACKGROUND: About 25% of the patients with nonischemic left ventricular (LV) systolic dysfunction improve spontaneously. However, the predictors for functional improvement are not known. We hypothesized that myocardial fibrosis, assessed by cardiac magnetic resonance (CMR) imaging, may predict the reversibility of nonischemic LV systolic dysfunction.
METHODS AND RESULTS: CMR was performed in 46 patients. Baseline and follow-up echocardiography was performed to assess the recovery of LV function. There were 24 patients with absence of delayed hyperenhancement (group 1) and 22 patients with delayed hyperenhancement (group 2). There were significant difference for the follow-up LV end-diastolic dimension (56.2 +/- 7.3 versus 62.6 +/- 11.9), LV end-systolic dimension (43.2 +/- 9.2 versus 52.8 +/- 12.6), and LV ejection fraction (LVEF) (46.8 +/- 12.4% versus 31.6 +/- 11.3%). Follow-up echocardiography of 19/24 (79.2%) patients in group 1 showed functional recovery, whereas only 2/22 (9.1%) patient in group 2 showed functional recovery. The absence of delayed hyperenhancement was associated with sensitivity, specificity, positive predictive value, and negative predictive value of 90.5%, 79.2%, 80.0%, and 90.9%, respectively.
CONCLUSION: Absence of delayed hyperenhancement demonstrated excellent sensitivity and negative predictive value in predicting functional recovery of nonischemic LV systolic dysfunction.
Full Text
http://www.sciencedirect.com/science/article/pii/S1071916405013230
DOI
10.1016/j.cardfail.2005.10.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108803
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