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Nanohybrids via a polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells

Authors
 Sung-Baek Seo  ;  Jaemoon Yang  ;  Eun-Sook Lee  ;  Yukyung Jung  ;  Kyujung Kim  ;  Sang-Yup Lee  ;  Donghyun Kim  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 Journal of Materials Chemistry, Vol.18(37) : 4402-4407, 2008 
Journal Title
 Journal of Materials Chemistry 
ISSN
 0959-9428 
Issue Date
2008
Abstract
Fluorescent polycation-coated magnetic nanohybrids (FPMNs) were synthesized for the marking of human mesenchymal stem cells (hMSCs) and non-invasive tracking by both magnetic resonance (MR) and optical imaging. FPMNs were prepared by a polycation-based nanoemulsion method using magnetic nanocrystals (MNCs) as MR probes and polycationic polyethylenimine (PEI) which not only enhanced the affinity for hMSCs but also increased colloidal stability in the aqueous phase. Polycation-coated magnetic nanohybrids (PMNs) were further conjugated with a fluorescent dye (fluorescein isothiocyanate) to serve as optical imaging agents. FPMNs exhibited excellent colloidal stability and biocompatibility as well as high affinity for hMSCs. MR and optical images of hMSCs treated with FPMNs clearly demonstrated abundant potential as brilliant dual-mode imaging agents.
Full Text
http://pubs.rsc.org/en/content/articlelanding/2008/jm/b804544e#!divAbstract
DOI
10.1039/B804544E
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
양재문(Yang, Jae Moon) ORCID logo https://orcid.org/0000-0001-7365-0395
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108219
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